ArticleBMC neurology2026
The association between ambulatory blood pressure monitoring and 90-day ischemic stroke following transient ischemic attack in hypertensive patients: a retrospective cohort study.
Article in BMC neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundIschemic stroke (IS) is a major public health challenge. Transient ischemic attack (TIA) serves as a critical warning sign, particularly in hypertensive patients where early risk stratification remains difficult. While ambulatory blood pressure monitoring (ABPM) parameters strongly associated with cerebrovascular events, their predictive value for post-TIA stroke in hypertension is unclear. This study evaluated ABPM parameters for predicting 90-day acute IS risk in hypertensive TIA patients.
methodsThis single-center retrospective cohort included 1,276 hypertensive patients with TIA. All underwent 24-hour ABPM within 48 h. The outcome was IS within 90 days. LASSO regression selected key variables from 20 ABPM indices. Their independent association with IS was assessed using multivariable Cox regression across four progressively adjusted models. Predictive performance was evaluated via receiver operator characteristic curve (ROC) curves, nonlinearity via restricted cubic splines (RCS), and robustness via subgroup analyses.
resultsLASSO identified five key variables: nighttime systolic blood pressure variability (nSBPCV), daytime systolic blood pressure load (dSBPL), morning blood pressure surge (MBPS), nighttime systolic blood pressure (nSBP) and duration of hypertension. After all the adjustments, these variables remained independent risk factors for the occurrence of IS within 90 days in patients with a history of hypertension who suffered from TIA (all P < 0.001). nSBPCV (AUC = 0.834) and dSBPL (AUC = 0.804) outperformed the ABCD2 score (AUC = 0.685). RCS revealed nonlinear association for hypertension duration, nSBPCV, and dSBPL with clear inflection points (5.9 years, 9.1%, 37.3%). Results were consistent across subgroups.
conclusionsIn hypertensive TIA patients, ABPM-derived parameters, especially nSBPCV and dSBPL, are strong predictors of 90-day IS risk, superior to ABCD2. The identified nonlinear relationships and inflection points provide actionable thresholds for personalized risk stratification and precise blood pressure management.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.