ArticleInternational journal of molecular medicine2026
Triptolide exerts antiviral effects and alleviates influenza A‑induced pneumonia by inhibiting the overactivation of absent in melanoma 2 signaling in immune cells.
Article in International journal of molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Influenza A (H1N1) virus‑induced pneumonia poses a significant clinical challenge because of excessive immune activation and limited targeted therapies. While current antivirals suppress viral replication, they fail to control absent in melanoma 2 (AIM2) inflammasome‑mediated hyperinflammation, a key driver of immunopathology and mortality. The present study investigated whether triptolide (TP) ameliorates H1N1‑induced pneumonia by targeting this unmet need. The results demonstrated that H1N1 infection reduced the levels of inflammatory cytokines in both human bronchial epithelial cells (HBEpiCs) and THP‑1 cells and decreased the adhesion between the two cell types. Furthermore, high‑dose H1N1 activation triggered the AIM2 signaling pathway in THP‑1 cells but not in HBEpiCs and decreased the viability of THP‑1 cells.
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