Evidence map›Paper›PMID 41993287›Full record

ArticlebioRxiv : the preprint server for biology2026

Serial Thermal Ablation Induces Abscopal Antitumor Immunity and Reveals Targetable CSF1R-Dependent Resistance in Pancreatic Cancer.

Lincoln N Strickland, Wendao Liu, MacKenzie V Demmel, Alyssa M Waller, Shwetapadma Dash, Khadija Turabi, Nicolette R Mardik, Casey J Van Kirk, Baylee O'Brien, Julie Rowe and 8 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Lincoln N StricklandDepartment of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, NE.ORCID 0000-0002-2347-4431
Wendao LiuThe University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Houston, Texas.ORCID 0000-0002-5124-9338
MacKenzie V DemmelDepartment of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, NE.ORCID 0009-0002-1877-9772
Alyssa M WallerDepartment of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, NE.ORCID 0009-0006-8123-298X
Shwetapadma DashDepartment of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, NE.ORCID 0009-0005-7914-0675
Khadija TurabiDepartment of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, NE.ORCID 0000-0002-0372-6435
Nicolette R MardikDepartment of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, TX.ORCID 0009-0004-9315-8583
Casey J Van KirkDepartment of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, NE.ORCID 0009-0000-2096-3144
Baylee O'BrienDepartment of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, TX.ORCID 0000-0003-4272-6654
Julie RoweDepartment of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, TX.ORCID 0000-0001-7583-7794
Putao CenDepartment of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, TX.ORCID 0000-0001-5633-311X
Kelsey A KluteFred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE.ORCID 0000-0002-4748-8520
Jesse L CoxDepartment of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, NE.ORCID 0000-0002-4590-7381
Zhongming ZhaoCenter for Precision Health, McWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX.ORCID 0000-0002-3477-0914
Sunil R HingoraniFred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE.ORCID 0000-0002-3869-8729
Curtis J WrayDepartment of Surgery, The University of Texas Health Science Center at Houston, Houston, TX.ORCID 0000-0003-4425-4566
Nirav C ThosaniDepartment of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, TX.ORCID 0000-0002-4607-6241
Jennifer M Bailey-LundbergDepartment of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, NE.ORCID 0000-0002-4750-106X

Funding

UNMC/EPPLEY CANCER CENTER SUPPORT GRANTP30CA036727 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI James Eudy · 1985 to 2026
$55.0M
A single-arm phase II study to evaluate the safety and efficacy of combination systematic chemotherapy and multiple rounds of endoscopic ultrasound-guided radiofrequency ablation in pancreatic cancerR01CA277161 · NCI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Jennifer Bailey Lundberg, Nirav Thosani · 2023 to 2026
$2.6M
Defining the role of Mst1/Mst2 in regulating metabolic alterations in Ras driven NSCLCR21CA249924 · NCI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LUNDBERG, JENNIFER BAILEY, YING, HAOQIANG · 2021 to 2022
$413k
NCI NIH HHS P30 CA036727NCI NIH HHS R01 CA277161NCI NIH HHS R21 CA249924
6 · The paper itself

Abstract

Thermal ablation is increasingly used for local control of pancreatic ductal adenocarcinoma (PDAC), but its capacity to induce systemic antitumor immunity and the mechanisms limiting this response remain incompletely defined. Using a bilateral

Identifiers

PMID41993287
PMCPMC13081821

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.