Evidence map›Paper›PMID 41993376›Full record

ArticlebioRxiv : the preprint server for biology2026

A genome-wide

Liang Bao, Jennifer Bradley, Vysakh Anandan, Katarzyna M Tyc, Zan Zhu, Josephina Anna Vossen, Valery-Francine Assi, Jasmine S Benbei, Nicai Zollar, Todd Kitten and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Liang BaoDepartment of Oral and Craniofacial Molecular Biology, Philips Institute for Oral Health Research, School of Dentistry, Virginia Commonwealth University, Virginia, USA.ORCID 0000-0002-0228-6124
Jennifer BradleyDepartment of Oral and Craniofacial Molecular Biology, Philips Institute for Oral Health Research, School of Dentistry, Virginia Commonwealth University, Virginia, USA.
Vysakh AnandanDepartment of Oral and Craniofacial Molecular Biology, Philips Institute for Oral Health Research, School of Dentistry, Virginia Commonwealth University, Virginia, USA.
Katarzyna M TycDepartment of Biostatistics, School of Public Health, Virginia Commonwealth University, Virginia, USA.
Zan ZhuDepartment of Oral and Craniofacial Molecular Biology, Philips Institute for Oral Health Research, School of Dentistry, Virginia Commonwealth University, Virginia, USA.
Josephina Anna VossenDepartment of Radiology, VCU School of Medicine, Virginia Commonwealth University, Virginia, USA.
Valery-Francine AssiDepartment of Oral and Craniofacial Molecular Biology, Philips Institute for Oral Health Research, School of Dentistry, Virginia Commonwealth University, Virginia, USA.
Jasmine S BenbeiDepartment of Oral and Craniofacial Molecular Biology, Philips Institute for Oral Health Research, School of Dentistry, Virginia Commonwealth University, Virginia, USA.
Nicai ZollarDepartment of Oral and Craniofacial Molecular Biology, Philips Institute for Oral Health Research, School of Dentistry, Virginia Commonwealth University, Virginia, USA.
Todd KittenDepartment of Oral and Craniofacial Molecular Biology, Philips Institute for Oral Health Research, School of Dentistry, Virginia Commonwealth University, Virginia, USA.ORCID 0000-0001-6097-7583
Ping XuDepartment of Oral and Craniofacial Molecular Biology, Philips Institute for Oral Health Research, School of Dentistry, Virginia Commonwealth University, Virginia, USA.ORCID 0000-0002-8368-801X

Funding

Virus Vector Shared ResourceP30CA016059 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Renato Martins · 1985 to 2026
$51.0M
Oral Streptococcal Fitness And Virulence genesR01DE030121 · NIDCR · VIRGINIA COMMONWEALTH UNIVERSITY · PI KITTEN, TODD O., XU, PING · 2021 to 2025
$2.5M
Comparative Experimental Evolution of Gene Essentiality in Streptococcus sanguinis and S. mutansR03DE034511 · NIDCR · VIRGINIA COMMONWEALTH UNIVERSITY · PI BAO, LIANG · 2025 to 2025
$311k
NCI NIH HHS P30 CA016059NIDCR NIH HHS R01 DE030121NIDCR NIH HHS R03 DE034511
6 · The paper itself

Abstract

Infective endocarditis (IE) is a life-threatening disease most often caused by blood-borne bacteria that infect previously damaged cardiac tissue. Despite the importance of this disease, the genetic basis for IE virulence remains poorly defined. Here, we present the first genome-wide

Indexed as

compensatory mechanisms of fitness defectscomprehensive non-essential gene knockout libraryIE-fitness factorsstreptococcal IEStreptococcus mutansStreptococcus sanguinisvertebrate IE models

Identifiers

PMID41993376
PMCPMC13081934

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.