ArticlebioRxiv : the preprint server for biology2026
Identity, ontogeny, and age-related changes in splenic white pulp macrophages in mouse and human spleen.
Kalyn R Thayer, Maxwell J Schleck, Yuliana V Sokolenko, Radmila A Nafikova, Zhan Yu, Ziyan Lu, Karolina J Senkow, Elsie G Bunyan, William T Plodzeen, Constance E Runyan and 15 more
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from itWhat it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
25 authors.
Kalyn R ThayerDivision of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine.ORCID 0000-0002-4067-2915 Maxwell J SchleckDivision of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine.ORCID 0009-0003-2490-723X Yuliana V SokolenkoDivision of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine.ORCID 0000-0001-9872-0484 Radmila A NafikovaDivision of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine.ORCID 0000-0003-2850-9178 Zhan YuDivision of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine.ORCID 0000-0003-4389-0384 Ziyan LuDivision of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine.ORCID 0000-0003-2901-3801 Karolina J SenkowDivision of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine.ORCID 0000-0001-9942-3529 Elsie G BunyanDivision of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine.ORCID 0009-0005-6589-6965 William T PlodzeenDivision of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine.ORCID 0009-0006-3430-7694 Constance E RunyanDivision of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine.ORCID 0000-0001-9335-7997 Rogan A GrantDivision of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine.ORCID 0000-0003-0655-0882 Suchitra SwaminathanRobert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine.ORCID 0000-0002-8292-122X Duc PhanRobert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine.ORCID 0009-0009-4446-4265 Hiam Abdala-ValenciaDivision of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine.ORCID 0000-0003-3384-5299 Stephanie C EisenbarthDivision of Allergy and Immunology, Northwestern University Feinberg School of Medicine.ORCID 0000-0002-1244-208X Mary CarnsDivision of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine.ORCID 0000-0002-5063-156X G R Scott BudingerDivision of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine.ORCID 0000-0002-3114-5208 Alexander V MisharinDivision of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine.ORCID 0000-0003-2879-3789 Funding
Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Devalingam Mahalingam · 1993 to 2026
$153.9MTissue resident macrophages regulate proteostasis in the aging lungP01AG049665 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI NAVDEEP S CHANDEL · 2015 to 2026
$26.9MTechnology CoreU19AI135964 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI RICHARD G WUNDERINK · 2018 to 2026
$24.7MThe Cell Phenotyping and Mouse CoreP01HL154998 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KAREN M RIDGE · 2021 to 2026
$18.9MMidwest Murine-Tissue Mapping Center (MM-TMC)U54AG079754 · NIA · UNIVERSITY OF MINNESOTA · PI GR Scott Budinger, Sundeep Khosla · 2022 to 2026
$11.5MSynergistic roles of lung autoantibodies, donor nonclassical monocytes and recipient classical monocytes in mediating primary graft dysfunctionP01HL169188 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Ankit Bharat · 2024 to 2026
$11.1MThe Neu-Lung Consortium: Neutrophilic Mechanisms of Inflammation, Injury, and Repair in Lung and Airways DiseasesU19AI181102 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Stephanie Caroline Eisenbarth, Alexander Misharin · 2024 to 2026
$9.3MRole of spleen educated monocytes in mediating ischemia-reperfusion injury followinglung transplant surgeryR01HL147575 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Ankit Bharat, GR Scott Budinger · 2019 to 2026
$5.5MPathogenesis of lung injury mediated by lung-restricted antibodiesR01HL147290 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Ankit Bharat, GR Scott Budinger · 2019 to 2026
$5.2MDonor nonclassical monocytes mediate primary graft dysfunction and remote organ injury following lung transplant surgeryR01HL145478 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Ankit Bharat, GR Scott Budinger · 2019 to 2026
$4.8MMacrophage Heterogeneity in Rheumatoid ArthritisR01AR080513 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Harris R Perlman, Deborah Rachelle Winter · 2022 to 2026
$3.3MMonocyte-derived alveolar macrophage drives inflammatory response to lung ozone exposureR01ES034350 · NIEHS · DUKE UNIVERSITY · PI Alexander Misharin, Robert Matthew Tighe · 2022 to 2026
$3.0MCSRD VA I01 CX001777NCI NIH HHS P30 CA060553NHLBI NIH HHS P01 HL154998NHLBI NIH HHS P01 HL169188NHLBI NIH HHS R01 HL145478NHLBI NIH HHS R01 HL147290NHLBI NIH HHS R01 HL147575NHLBI NIH HHS R01 HL153312NHLBI NIH HHS R01 HL158139NHLBI NIH HHS R01 HL176632NIAID NIH HHS U19 AI135964NIAID NIH HHS U19 AI181102NIAMS NIH HHS R01 AR080513NIA NIH HHS P01 AG049665NIA NIH HHS U54 AG079754NIEHS NIH HHS R01 ES034350NIH HHS S10 OD011996NIH HHS S10 OD026814
6 · The paper itselfAbstract
The spleen contains diverse macrophage subsets that remove aged erythrocytes, prevent the dissemination of circulating pathogens, and shape the adaptive immune response
Identifiers
PMID41993466
PMCPMC13081898
What Socratic holds
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