Evidence mapPaperPMID 41993545Full record

ArticlebioRxiv : the preprint server for biology2026

Connectome-based spatial statistics enabling large-scale population analyses of human connectome across cohorts.

Tengfei Li, Xifeng Wang, Martin Cole, Zehui Sun, Zhiwen Jiang, Xinjie Qian, Shan Gao, Tianyou Luo, Maxime Descoteaux, Jason L Stein and 5 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Tengfei LiDepartment of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.ORCID 0000-0001-6142-3865
Xifeng WangDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.
Martin ColeDepartment of Psychiatry, University of Rochester, Rochester, New York, United Stated.
Zehui SunDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.
Zhiwen JiangDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.
Xinjie QianDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.
Shan GaoDepartment of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.
Tianyou LuoDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.
Maxime DescoteauxDepartment of Computer Science, University of Sherbrooke, Sherbrooke, Quebec, Canada.
Jason L SteinDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.ORCID 0000-0003-4829-0513
Xiao WangDepartment of Statistics, Purdue University, West Lafayette, Indiana, United States.
Thomas E NicholsNuffield Department of Population Health of the University of Oxford, Oxford, England.ORCID 0000-0002-4516-5103
Heping ZhangDepartment of Biostatistics, Statistics, and Child Study Center, Yale University, New Haven, Connecticut, United States.ORCID 0000-0002-0688-4076
Zhengwu ZhangDepartment of Statistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.
Hongtu ZhuDepartment of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.

Funding

Unified and fair multimodal representation learning for autoimmune diseasesOT2OD038045 · UNIV OF NORTH CAROLINA CHAPEL HILL · 2025 to 2025
$2.5M
Mapping the Causal Genetic-Imaging-Clinical Pathway for Alzheimer's DiseaseRF1AG082938 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Bingxin Zhao, Hongtu Zhu · 2023 to 2023
$2.2M
Construction and Application of Comprehensive Knowledge Graphs for Alzheimer's DiseaseR01AG085581 · UNIV OF NORTH CAROLINA CHAPEL HILL · 2025 to 2025
$1.2M
SCH: Novel Multi-View Statistical Machine Learning for Alzheimer's DiseaseRF1AG098697 · NEW YORK UNIVERSITY · 2025 to 2025
$1.0M
AD GxE: In vivo and in vitro modeling of gene x environment interactionsU01AG088667 · UNIV OF NORTH CAROLINA CHAPEL HILL · 2025 to 2025
$738k
Shared neural basis and genetic architecture of psychiatric disordersR01MH136055 · UNIVERSITY OF PENNSYLVANIA · 2025 to 2025
$703k
Infant Cognitive Growth Prediction via Centile-based Brain Development and Meta MatchingR21HD120911 · UNIV OF NORTH CAROLINA CHAPEL HILL · 2025 to 2025
$414k
Tracking brain structural trajectories for early detection and prognosis of Alzheimer's DiseaseK01AG095286 · UNIV OF NORTH CAROLINA CHAPEL HILL · 2025 to 2025
$143k
NIA NIH HHS K01 AG095286NIA NIH HHS R01 AG085581NIA NIH HHS RF1 AG082938NIA NIH HHS RF1 AG098697NIA NIH HHS U01 AG088667NICHD NIH HHS R21 HD120911NIH HHS OT2 OD038045NIMH NIH HHS R01 MH136055
6 · The paper itself

Abstract

Large-scale population analyses of structural connectome organization remain challenging because of cross-subject alignment, pathway interpretability and computational burden. No widely adopted standard exists for systematic evaluation across processing methods. We developed connectome-based spatial statistics (CBSS), a scalable framework for anatomically aligned and functionally informed quantification of white-matter microstructure that yields atlas-defined pathways organized into

Identifiers

PMID41993545
PMCPMC13081836

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.