Evidence map›Paper›PMID 41993546›Full record

ArticlebioRxiv : the preprint server for biology2026

Transcriptional profiling of extraocular motor neurons reveals

Emily Gershowitz, Kyla Rose Hamling, Başak Rosti, Hannah Gelnaw, Grace Xiang, Cheryl Quainoo, Dena Goldblatt, Paige Leary, David Schoppik

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Emily GershowitzDepts. of Neuroscience, Otolaryngology, and the Institute for Translational Neuroscience, New York University Grossman School of Medicine, New York, NY USA.ORCID 0009-0008-4732-4340
Kyla Rose HamlingDepts. of Neuroscience, Otolaryngology, and the Institute for Translational Neuroscience, New York University Grossman School of Medicine, New York, NY USA.ORCID 0000-0001-5408-9256
Başak RostiDepts. of Neuroscience, Otolaryngology, and the Institute for Translational Neuroscience, New York University Grossman School of Medicine, New York, NY USA.ORCID 0009-0008-9838-8272
Hannah GelnawDepts. of Neuroscience, Otolaryngology, and the Institute for Translational Neuroscience, New York University Grossman School of Medicine, New York, NY USA.ORCID 0000-0002-7970-796X
Grace XiangDepts. of Neuroscience, Otolaryngology, and the Institute for Translational Neuroscience, New York University Grossman School of Medicine, New York, NY USA.
Cheryl QuainooDepts. of Neuroscience, Otolaryngology, and the Institute for Translational Neuroscience, New York University Grossman School of Medicine, New York, NY USA.
Dena GoldblattDepts. of Neuroscience, Otolaryngology, and the Institute for Translational Neuroscience, New York University Grossman School of Medicine, New York, NY USA.ORCID 0000-0003-0333-2433
Paige LearyDepts. of Neuroscience, Otolaryngology, and the Institute for Translational Neuroscience, New York University Grossman School of Medicine, New York, NY USA.ORCID 0000-0002-0888-466X
David SchoppikDepts. of Neuroscience, Otolaryngology, and the Institute for Translational Neuroscience, New York University Grossman School of Medicine, New York, NY USA.ORCID 0000-0001-7969-9632

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Richard Lewis Possemato · 1985 to 2026
$83.1M
Functional maturation of interneurons that mediate the vestibulo-ocular reflex - Renewal - Resubmission - 1R01DC017489 · NIDCD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI David Schoppik · 2019 to 2026
$4.8M
Training Program in Molecular, Cellular, and Translational NeuroscienceT32NS086750 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JEREMY S DASEN, Katherine Nagel · 2014 to 2026
$2.4M
Determinants of extraocular motor neuron subtype diversityR01EY035691 · NEI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI David Schoppik · 2024 to 2026
$1.5M
Cellular Mechanisms of Behavioral Development in the Vestibulospinal CircuitF31DC019554 · NIDCD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI HAMLING, KYLA · 2021 to 2023
$104k
Molecular and sensory foundations of vestibular reflex circuit assembly in the larval zebrafishF99NS129179 · NINDS · NEW YORK UNIVERSITY · PI GOLDBLATT, DENA · 2022 to 2023
$84k
Developmental Contributions to the Functional Maturation of the Vestibulo-Ocular ReflexF31DC020910 · NIDCD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI LEARY, PAIGE · 2023 to 2024
$65k
NCI NIH HHS P30 CA016087NEI NIH HHS R01 EY035691NIDCD NIH HHS F31 DC019554NIDCD NIH HHS F31 DC020910NIDCD NIH HHS R01 DC017489NINDS NIH HHS F99 NS129179NINDS NIH HHS T32 NS086750
6 · The paper itself

Abstract

Strabismus, or misalignment of the eyes, is a heritable disorder frequently associated with vision loss and decreased quality of life. Incomitant strabismus, where the degree of misalignment differs based on gaze angle, can arise from mutations in genes that regulate the development of extraocular motor neurons. To date, few such genes have been identified. The extraocular motor system is highly conserved across vertebrates, suggesting a comparative transcriptomic discovery approach would be fruitful. Using bulk and single-cell sequencing in a small accessible vertebrate, the larval zebrafish, we identified genes expressed in subpopulations of extraocular motor neurons in cranial nuclei nIII/nIV. We next assessed extraocular motor neuron number and vestibulo-ocular reflex performance after CRISPR/Cas9-mediated mutagenesis of three genes with suggestive expression patterns:

Identifiers

PMID41993546
PMCPMC13081939

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.