Evidence map›Paper›PMID 41993555›Full record

ArticlebioRxiv : the preprint server for biology2026

Gut microbiome-dependent IL-1 signaling is a mediator of ACVR1

Hannah M Herzog, Camille Fang, Liam Lam, Katherine Jin, Ariane Zamarioli, Ethan Dinh, Chhedi Lal Gupta, Aditi Sharma, Tania Moody, Jessica L Pierce and 13 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Hannah M HerzogDivision of Endocrinology and Metabolism and the Institute for Human Genetics, Department of Medicine, University of California, San Francisco, CA 94143.ORCID 0009-0007-1264-3395
Camille FangDivision of Endocrinology and Metabolism and the Institute for Human Genetics, Department of Medicine, University of California, San Francisco, CA 94143.
Liam LamDivision of Endocrinology and Metabolism and the Institute for Human Genetics, Department of Medicine, University of California, San Francisco, CA 94143.
Katherine JinDivision of Endocrinology and Metabolism and the Institute for Human Genetics, Department of Medicine, University of California, San Francisco, CA 94143.
Ariane ZamarioliDivision of Endocrinology and Metabolism and the Institute for Human Genetics, Department of Medicine, University of California, San Francisco, CA 94143.
Ethan DinhOral and Craniofacial Sciences Graduate Program, School of Dentistry, University of California, San Francisco, CA 94143.
Chhedi Lal GuptaBenioff Center for Microbiome Medicine, Department of Medicine, University of California, San Francisco, San Francisco CA 94143.
Aditi SharmaDivision of Endocrinology and Metabolism and the Institute for Human Genetics, Department of Medicine, University of California, San Francisco, CA 94143.
Tania MoodyDivision of Endocrinology and Metabolism and the Institute for Human Genetics, Department of Medicine, University of California, San Francisco, CA 94143.
Jessica L PierceDivison of Endocrinology, Metabolism, and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322.
Michael S HohlDivison of Endocrinology, Metabolism, and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322.
Sarah W TakimotoDivision of Endocrinology and Metabolism and the Institute for Human Genetics, Department of Medicine, University of California, San Francisco, CA 94143.
Svetlana LyalinaGladstone Institutes, San Francisco, CA.
Kelly L WentworthDivision of Endocrinology and Metabolism and the Institute for Human Genetics, Department of Medicine, University of California, San Francisco, CA 94143.
Kristie YuUniversity of California, Los Angeles, Los Angeles CA 90095.
Vivian F LuCentral Michigan University College of Medicine, Mount Pleasant, MI 4885.
Isadora MamikunianDivision of Endocrinology and Metabolism and the Institute for Human Genetics, Department of Medicine, University of California, San Francisco, CA 94143.
Natasha K HuntDepartment of Orthopaedic Surgery, University of California San Francisco, 400 Parnassus Avenue, San Francisco, CA 94143.ORCID 0009-0003-8176-3631
Susan LynchBenioff Center for Microbiome Medicine, Department of Medicine, University of California, San Francisco, San Francisco CA 94143.
Katherine S PollardGladstone Institutes, San Francisco, CA.
Christopher J HernandezDepartment of Orthopaedic Surgery, University of California San Francisco, 400 Parnassus Avenue, San Francisco, CA 94143.ORCID 0000-0002-0712-6533
Daniel S PerrienDivison of Endocrinology, Metabolism, and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322.
Edward C HsiaoDivision of Endocrinology and Metabolism and the Institute for Human Genetics, Department of Medicine, University of California, San Francisco, CA 94143.ORCID 0000-0001-8924-106X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammatory diseases cause significant morbidity and mortality, but their pathobiology is often difficult to dissect due to complex genetic-environmental interactions. Genetic forms of heterotopic ossification, such as fibrodysplasia ossificans progressiva (FOP), reduce genetic variability, allowing careful dissection of non-genetic drivers of inflammation. While >95% of FOP patients harbor the

Identifiers

PMID41993555
PMCPMC13081864

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.