Evidence map›Paper›PMID 41993564›Full record

ArticlebioRxiv : the preprint server for biology2026

Loss of MITF activity leads to emergent cell states from the melanocyte stem cell lineage.

Alessandro Brombin, Stephanie MacMaster, Jana Travnickova, Cameron Wyatt, Hannah Brunsdon, Emma Ramsey, Hong Nhung Vu, Eirikur Steingrimsson, Colin Kenny, Tamir Chandra and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Alessandro BrombinMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital Campus, EH4 2XU, Edinburgh, United Kingdom.
Stephanie MacMasterMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital Campus, EH4 2XU, Edinburgh, United Kingdom.
Jana TravnickovaMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital Campus, EH4 2XU, Edinburgh, United Kingdom.
Cameron WyattMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital Campus, EH4 2XU, Edinburgh, United Kingdom.
Hannah BrunsdonMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital Campus, EH4 2XU, Edinburgh, United Kingdom.
Emma RamseyMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital Campus, EH4 2XU, Edinburgh, United Kingdom.
Hong Nhung VuDepartment of Biochemistry and Molecular Biology, BioMedical Center, Faculty of Medicine, University of Iceland, Sturlugata 8, 102, Reykjavík, Iceland.
Eirikur SteingrimssonDepartment of Biochemistry and Molecular Biology, BioMedical Center, Faculty of Medicine, University of Iceland, Sturlugata 8, 102, Reykjavík, Iceland.ORCID 0000-0001-5826-7486
Colin KennyDepartment of Surgery, College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Tamir ChandraDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
E Elizabeth PattonMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital Campus, EH4 2XU, Edinburgh, United Kingdom.ORCID 0000-0002-2570-0834

Funding

Establishing an in-vivo Sleeping-Beauty Screen to Identify and Characterize Novel Drivers of Melanomagenesis in a Nevi-Prone Zebrafish Model.R03CA297549 · NCI · UNIVERSITY OF IOWA · PI KENNY, COLIN P · 2025 to 2025
$156k
NCI NIH HHS R03 CA297549Wellcome Trust
6 · The paper itself

Abstract

How embryonic cells generate large clones of cells in the adult represents a fundamental question in biology. Here using melanocyte stem cells (McSCs) in the zebrafish as a model we explore the function of the master melanocyte transcription factor (MITF) in safeguarding McSCs in embryonic development and their potential to pigment large clones in the adult. MITF is well known is for its role in the specification of melanoblasts from the neural crest (NC) and their differentiation into melanocytes, yet little is known about how this activity shapes the stem cell lineages. Here, we use live imaging coupled with single-cell transcriptomics and lineage tracing to show that MITF (

Indexed as

lineage tracingmelanocyte lineageMelanocyte stem cellsmitfaMITF activityneural crest cellspigment stem cellsscRNA-seqzebrafish

Identifiers

PMID41993564
PMCPMC13082085

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.