Evidence map›Paper›PMID 41994141›Full record

ArticleResearch square2026

Spatial Transcriptomics and Dual Dye Mapping Identify Wnt-Driven BBB Protection in Endothelial EphA4-Deficiency.

Caroline de Jager, Jing Ju, Marco Corbo, Karan Patel, Michelle Theus

Abstract readPreprint
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Caroline de JagerVirginia Tech.
Jing JuVirginia Tech.
Marco CorboVirginia Tech.
Karan PatelVirginia Tech.
Michelle TheusVirginia Tech.

Funding

Divergent age-dependent peripheral innate immune response following TBIR01NS119540 · NINDS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI THEUS, MICHELLE LEE · 2021 to 2025
$2.6M
Novel mechanisms suppressing the pro-resolving phenotype of peripheral innate immunity following traumatic brain injuryR01NS121103 · NINDS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI THEUS, MICHELLE LEE · 2021 to 2025
$2.5M
NINDS NIH HHS R01 NS119540NINDS NIH HHS R01 NS121103
6 · The paper itself

Abstract

Blood-brain barrier (BBB) disruption is a key pathological event following traumatic brain injury (TBI), yet its molecular and spatial characteristics remain incompletely understood. Here, we developed a dual dye-labeling system to assess the temporal and spatial dynamics of BBB permeability following controlled cortical impact (CCI) injury in

Indexed as

blood-brain barrier (BBB)brain microvasculatureEph signalingneuroprotectionspatial transcriptomicstraumatic brain injury (TBI)

Identifiers

PMID41994141
PMCPMC13082128

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.