ArticleiScience2026
Directional alignment of different cell types organizes planar cell polarity.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Mathematical modeling of planar cell polarity: principles, approaches, and open questions.NPJ systems biology and applications · 2026Review
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intercellular coupling between core PCP proteins is essential for unidirectional polarization of epithelial cells, known as planar cell polarity (PCP). While imbalances in core PCP protein levels between adjacent cells disrupt PCP in some tissues, other tissues maintain PCP despite containing multiple cell types with distinct core PCP protein abundance. How such tissues tolerate these imbalances remains unclear. Here, we analyzed how the spatial distribution of cell types contributes to PCP maintenance using a previously established mathematical model. Systematic simulations showed that the accuracy of PCP maintenance under core PCP protein imbalance strongly depends on cell-type distribution patterns. We then applied deep learning and statistical modeling to identify critical features, revealing that the orientation of cell-type alignment is a key determinant of PCP robustness. Such directional cell-type alignment was observed in the mouse oviduct. Our findings highlight an overlooked role of tissue cell-type organization in PCP maintenance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.