ArticleFrontiers in medicine2026
Association between the neutrophil-to-albumin ratio and mortality in patients undergoing tracheal intubation: a retrospective cohort study.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Introduction: Tracheal intubation in intensive care unit (ICU) patients is associated with significant risks, necessitating simple mortality predictors. We investigated the relationship between neutrophil percentage-to-albumin ratio (NPAR) and in-hospital and ICU mortality in intubated patients. Methods: This retrospective cohort study analyzed 1,401 intubated ICU patients from MIMIC-IV. Multivariable Cox regression and smooth curve fitting were used to assess the association between NPAR and mortality. A two-stage linear regression model and threshold analysis evaluated nonlinear relationships. Results: Among patients (mean age 62.7 ± 17.1 years; 43.6% female), NPAR exhibited a U-shaped relationship with mortality, with an inflection point at 2.2 observed in this cohort. Below this inflection point, hazard ratios (HRs) were 0.656 (95% CI: 0.492-0.875) for in-hospital mortality and 0.586 (95% CI: 0.413-0.831) for ICU mortality. Above 2.2, HRs increased to 1.187 (95% CI: 1.097-1.286) and 1.15 (95% CI: 1.047-1.264), respectively. Conclusion: NPAR demonstrates a U-shaped association with mortality in intubated ICU patients, with elevated risks above 2.2. Further large-scale studies are needed to validate these findings.
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