Evidence map›Paper›PMID 41994641›Full record

ArticleFrontiers in oncology2026

Ginsenoside-Rh2 inhibits U251 glioma cell migration and invasion via the Gab2/Akt2 pathway.

Wei Sun, Ruifang Li, Linjuan Wang, Wenjie Han, Jiake Li, Shuangli Xu, Xiuning Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wei Sun *Department of Emergency Medicine, Affiliated Hospital of Shandong Second Medical University, Weifang, China.
Ruifang Li *Department of Pathogenic Biology, Shandong Second Medical University, Weifang, China.
Linjuan WangDepartment of Rehabilitation, Weifang Hospital of Traditional Chinese Medicine, Weifang, China.
Wenjie HanHemodialysis Room, Affiliated Hospital of Shandong Second Medical University, Weifang, China.
Jiake LiDepartment of Emergency Medicine, Affiliated Hospital of Shandong Second Medical University, Weifang, China.
Shuangli XuQingdao Medical College, Qingdao University, Qingdao, China.
Xiuning SunDepartment of Pathogenic Biology, Shandong Second Medical University, Weifang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Glioma, the most common primary intracranial tumor, exhibits high recurrence and mortality rates. Ginsenoside-Rh2 (GS-Rh2), an active compound from Objective: To investigate the effects and mechanisms of GS-Rh2 on glioma cell migration and invasion through the Gab2/Akt2 signaling pathway. Methods: U251 glioma cells were treated with GS-Rh2 Results: GS-Rh2 significantly inhibited U251 cell proliferation, migration, and invasion both Conclusions: GS-Rh2 inhibits migration and invasion of U251 glioma cells by decreasing Gab2 expression and Akt2 phosphorylation, suggesting that GS-Rh2 targets the Gab2/Akt2 signaling axis.

Indexed as

Akt2Gab2ginsenoside-Rh2gliomainvasion

Identifiers

PMID41994641
PMCPMC13079109

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.