ArticleCureus2026
Anti-3-Hydroxy-3-Methylglutaryl-Coenzyme A (HMG-CoA) Reductase Negative Statin-Induced Necrotizing Myopathy: A Challenging Case.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present a case of a man in his early 70s who presented to the emergency department with two weeks of diffuse muscle weakness and dark-colored urine. His history of present illness was negative for obvious inciting events based on the admission history and physical exam. Laboratory tests in the emergency department (ED) showed evidence of end-organ dysfunction, including elevated liver enzymes with aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels of 1,197 and 1,718 IU/L, respectively, an elevated creatinine (Cr) level of 1.44 mg/dL, and significant muscle injury indicated by a creatine phosphokinase (CPK) level of 20,000 IU/L. An unspecified myopathy was high on the differential. Workup was negative for autoimmune or rheumatologic causes of myositis, and statin-induced necrotizing myopathy became the top differential. The patient was treated with pulse-dose steroids. His hospital course was complicated by acute kidney failure requiring dialysis, with eventual recovery of kidney function and normalization of clinical and laboratory findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.