Trial reportDiabetes, obesity & metabolism2026
Effects of Premeal Versus Postmeal Metformin Administration on Postmeal Glycemic Control in Individuals With Type 2 Diabetes Mellitus: A Randomized, 8-Week Crossover Study.
Trial report in Diabetes, obesity & metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
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Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
aimsTo evaluate the effects of premeal versus postmeal metformin administration on postmeal glycemic control in individuals with type 2 diabetes mellitus receiving metformin monotherapy.
methodsAll participants were randomly assigned to receive immediate-release metformin either 30-60 min before or immediately after meal for 4 weeks, and crossed over to the alternate regimen for another 4 weeks. Standardized mixed-meal tests with glucose and insulin measurements were performed, and fructosamine was measured at baseline and at the end of each intervention. Continuous glucose monitoring (CGM) was applied to all during the last week of each intervention. Data were expressed as mean ± SD or estimated mean [95% CI] and were analysed using multilevel mixed-effects linear regression. The primary objective was to compare postmeal glucose responses to a standardized mixed-meal between groups. Secondary objectives were to assess CGM-derived postmeal glucose, fructosamine and insulin responses to a standardized mixed-meal.
resultsTwenty-two women (age 49.5
conclusionsPremeal immediate-release metformin reduces postmeal glycemic excursions more effectively than postmeal administration. This simple timing strategy may provide benefit for individuals who have predominant postmeal hyperglycemia.
trial registrationThai Clinical Trials Registry number: 20241127004.
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