ArticlePharmacology research & perspectives2026
Behavioral Domain-Specific Effects of Positive Modulation of α5 and α6 GABA
Đorđe Đorović, Jovana Aranđelović, Jana Ivanović, Kristina Jezdić, Bojan Batinić, Dishary Sharmin, Prithu Mondal, James M Cook, Miroslav M Savić
Abstract read
In one paragraphArticle in Pharmacology research & perspectives, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
9 authors.
Đorđe ĐorovićInstitute of Anatomy "Niko Miljanić", School of Medicine, University of Belgrade, Belgrade, Serbia.
Jovana AranđelovićDepartment of Pharmacology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.
Jana IvanovićDepartment of Pharmacology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.
Kristina JezdićDepartment of Pharmacology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.
Bojan BatinićDepartment of Physiology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.
Dishary SharminDepartment of Chemistry and Biochemistry, Milwaukee Institute for Drug Discovery, University of Wisconsin, Milwaukee, Wisconsin, USA.
Prithu MondalDepartment of Chemistry and Biochemistry, Milwaukee Institute for Drug Discovery, University of Wisconsin, Milwaukee, Wisconsin, USA.
James M CookDepartment of Chemistry and Biochemistry, Milwaukee Institute for Drug Discovery, University of Wisconsin, Milwaukee, Wisconsin, USA.
Miroslav M SavićDepartment of Pharmacology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.ORCID 0000-0002-6934-9193 Funding
Benzodiazepine Choice and Polydrug UseR01DA054177 · NIDA · UNIVERSITY OF MISSISSIPPI MED CTR · PI Sally L Huskinson · 2022 to 2026
$2.5MGABA-A receptor subtype mechanisms and the abuse-related effects of alcoholR01AA029023 · NIAAA · UNIVERSITY OF MISSISSIPPI MED CTR · PI PLATT, DONNA M · 2020 to 2024
$2.4MDesign of New Therapeutic Agents to Treat SchizophreniaR01MH096463 · NIMH · UNIVERSITY OF WISCONSIN MILWAUKEE · PI COOK, JAMES M · 2013 to 2017
$1.9MSynthesis of Alpha2/Alpha3 GABA Agonists to Treat Neuropathic PainR01NS076517 · NINDS · UNIVERSITY OF WISCONSIN MILWAUKEE · PI COOK, JAMES M · 2012 to 2015
$1.3MNational Science Foundation CHE- 1625735NIH HHS 2R01 DA043204-06A1NIH HHS R01 AA029023NIH HHS R01 DA054177NIH HHS R01 MH096463NIH HHS R01 NS076517Science Fund of the Republic of Serbia 7749108
6 · The paper itselfAbstract
Impulsivity is an understudied area of post-traumatic stress disorder, a debilitating disorder specifically associated with stress. We examined reward-related impulsive behavior, anxiety-like behavior, locomotor activity and social behavior in the absence and presence of protracted pharmacological positive modulation of α5- and α6-GABA
Indexed as
Receptors, GABA-AStress, PsychologicalAnimalsAnxietyBehavior, AnimalDisease Models, AnimalImpulsive BehaviorLocomotionMaleMaternal DeprivationRatsRats, Sprague-DawleyRewardSocial BehaviorGabra5 protein, ratReceptors, GABA-ADK‐I‐56‐1GL‐II‐73impulsivitymotivationrat model of double‐hit stressvariable delay‐to‐signal paradigmα5 GABAA receptorsα6 GABAA receptors
Identifiers
PMID41995413
PMCPMC13088882
What Socratic holds
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