Evidence map›Paper›PMID 41995474›Full record

ReviewJournal of Parkinson's disease2026

Stem cell treatments and Parkinson's disease: Science and misconceptions.

Athena Stamper, Harry Bulstrode, Roger A Barker

Abstract readReview
In one paragraph

Review in Journal of Parkinson's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Athena StamperCambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.ORCID 0000-0002-2663-8729
Harry BulstrodeCambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Roger A BarkerCambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.ORCID 0000-0001-8843-7730

Funding

Wellcome Trust
6 · The paper itself

Abstract

Parkinson's disease (PD) is a common neurodegenerative disorder associated with the accumulation of alpha-synuclein in Lewy bodies and Lewy neurites, as well as cell loss, including ventral midbrain dopaminergic (vmDA) neurons in the substantia nigra. This degeneration is responsible for some of the characteristic motor features of PD, which, in the early stages of the disease, can be successfully treated pharmacologically. However, in later stages of the disease, the efficacy of these drugs declines, and they can cause side effects. Dopamine cell therapy, which involves replacing lost vmDA neurons by implanting new exogenous ones, is a promising alternative. While research on dopamine cell therapies has made substantial progress over the last few decades, from early foetal transplants to stem cell-derived transplants currently in clinical trials, it is also susceptible to potential misconceptions. This review summarises the past, present, and future of this therapeutic strategy whilst also discussing these potential misconceptions. In doing so, the status of dopamine cell therapy for PD will be critically summarised.

Indexed as

cell therapyclinical trialsmisconceptionsneurosurgeryParkinson's diseasepreclinical studiesstem cell biology

Identifiers

PMID41995474
PMCPMC13443083

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.