ArticleMedicine2026
Structural and functional changes related to cognition in patients with early subcortical ischemic vascular disease: A cross-sectional MRI study.
Article in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Subcortical ischemic vascular disease (SIVD) is a key contributor to vascular cognitive impairment, yet early-stage SIVD is underexplored despite its link to cognitive decline. This study investigates structural and functional changes in SIVD patients with and without cognitive impairment. Twenty-five individuals of subcortical ischemic vascular disease with normal cognition, 25 individuals with subcortical ischemic vascular cognitive impairment (SVCI), and 23 normal controls were enrolled. Voxel-based morphometry was used to assess differences in gray matter volume (GMV) across 3 groups by one-way analysis of variance. Pearson correlation coefficients were computed between voxel-based morphometry-identified seeds and all brain voxels derived from the resting-state functional magnetic resonance imaging analyses to evaluate the alterations of functional connectivity (FC). Spearman correlation analyses were performed to examine the relationships between altered GMV, abnormal FC, and cognitive assessments. Compared with normal controls, the SVCI group showed significant reductions in GMV in prefrontal regions (orbitofrontal cortex, gyrus rectus, inferior frontal gyrus), temporal lobe (olfactory cortex, superior temporal gyrus), insula, and subcortical areas (thalamus, caudate). The subcortical ischemic vascular disease with normal cognition group exhibited GMV loss in the right orbitofrontal cortex. FC analyses revealed hypoconnectivity in cortical-subcortical circuits as well as ipsilateral and contralateral cognitive-related regions. Several GMV and FC alterations in the SVCI group were correlated with neuropsychological assessments, including the Stroop Color-Word Test II and Trail Making Test B. Early-stage SIVD patients exhibit structural and functional abnormalities linked to cognitive deficits. The right orbitofrontal cortex may serve as a potential imaging biomarker for early detection of SIVD.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.