ReviewMedicine2026
Research progress on the regulation of microglia and astrocyte functions by protein lactylation in cerebral ischemia-reperfusion injury: A review.
Review in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Protein lactylation, a novel posttranslational modification, has garnered significant attention for its regulatory mechanisms in cerebral ischemia-reperfusion injury. This review highlights the critical roles of protein lactylation in regulating microglia and astrocytes functions. By modulating the activation of microglia and astrocytes, inflammatory responses, and antioxidative stress, protein lactylation plays a pivotal role in neural repair and regeneration. Following cerebral ischemia-reperfusion injury, lactylation enhances the phagocytic activity of microglia, facilitates the clearance of necrotic cells, reduces the secretion of pro-inflammatory cytokines, and thus protects neurons. In astrocytes, lactylation modification supports blood-brain barrier integrity, provides nutritional support, and regulates antioxidative enzymes, further promoting neuronal survival and functional recovery. Further investigation into the molecular mechanisms of protein lactylation, its specific roles in glial cells, the development of novel lactylation regulators, and its interactions with other posttranslational modifications will offer new insights and directions for the treatment of cerebral ischemia-reperfusion injury.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.