Evidence map›Paper›PMID 41995874›Full record

ArticleEuropean journal of pediatrics2026

Sex- and body surface area-specific distribution and developmental trends of left ventricular structure and function during early adolescence.

Yawen Deng, Liyuan Xu, Shanshan Li, Jiao Yang, Guowen Liu, Hongju Zhang, Ruijuan Su, Li Xue, Kexin Zhu, Ning Ma

Abstract read
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Article in European journal of pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yawen DengDepartment of Echocardiography, Heart Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Heart CenterNo. 56 Nanlishi Road, 100045, Beijing, Xicheng District, China.
Liyuan XuDepartment of Echocardiography, Heart Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Heart CenterNo. 56 Nanlishi Road, 100045, Beijing, Xicheng District, China.
Shanshan LiDepartment of Echocardiography, Heart Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Heart CenterNo. 56 Nanlishi Road, 100045, Beijing, Xicheng District, China.
Jiao YangDepartment of Echocardiography, Heart Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Heart CenterNo. 56 Nanlishi Road, 100045, Beijing, Xicheng District, China.
Guowen LiuDepartment of Echocardiography, Heart Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Heart CenterNo. 56 Nanlishi Road, 100045, Beijing, Xicheng District, China.
Hongju ZhangDepartment of Echocardiography, Heart Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Heart CenterNo. 56 Nanlishi Road, 100045, Beijing, Xicheng District, China.
Ruijuan SuDepartment of Echocardiography, Heart Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Heart CenterNo. 56 Nanlishi Road, 100045, Beijing, Xicheng District, China.
Li XueDepartment of Echocardiography, Heart Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Heart CenterNo. 56 Nanlishi Road, 100045, Beijing, Xicheng District, China.
Kexin ZhuDepartment of Echocardiography, Heart Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Heart CenterNo. 56 Nanlishi Road, 100045, Beijing, Xicheng District, China.
Ning MaDepartment of Echocardiography, Heart Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Heart CenterNo. 56 Nanlishi Road, 100045, Beijing, Xicheng District, China. maning_echo@163.com.

Funding

Capital's Funds for Health Improvement and Research YH, Grant No.2022-1G-4262
6 · The paper itself

Abstract

To characterize sex- and body surface area (BSA)-related distributional patterns and developmental trends of left ventricular (LV) structure and function in healthy early adolescents. This cross-sectional study included 417 healthy children aged 10-13 years, stratified by BSA (0.90-1.20, 1.20-1.50, and 1.50-1.80 m

conclusionsIn healthy early adolescents, LV structure and volumes scale primarily with BSA, whereas LV functional indices are largely stable across the BSA spectrum. Sex differences are small and mainly reflected by a curved shape, supporting the use of BSA-stratified (rather than sex-specific) reference intervals for this age group. WHAT IS KNOWN: • Early adolescence is a key pubertal growth phase, but data on cardiac adaptation and remodeling are limited. • Current reference systems recommend BSA-based rather than age-based stratification, but whether there are sex differences in BSA levels in early adolescence remains unclear. WHAT IS NEW: • We provide BSA-stratified reference intervals and model BSA-related LV structure/function patterns in early adolescents using kernel density and GAMs. • In early adolescence, sex differences are clinically negligible and mainly at higher BSA, supporting BSA-based rather than age- or sex-specific references.

Indexed as

Body Surface AreaHeart VentriclesVentricular Function, LeftAdolescentChildCross-Sectional StudiesEchocardiographyFemaleHumansMaleReference ValuesSex FactorsStroke VolumeEarly adolescenceGeneralized additive modelHeight^2.7-indexed LVMKernel density estimationLeft ventricular structure and function

Identifiers

PMID41995874

What Socratic holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.