Evidence map›Paper›PMID 41995997›Full record

ArticleMolecular biology reports2026

Potential Role of MicroRNA-410-5p and BIRC7 Gene Pathways in Recurrent Miscarriage in an Egyptian Population.

Nesma G Farag, Amany O Mohamed, Mahmoud Abdel-Aleem, Thorya S El-Deeb, Shimaa A Elghazally, Mohamed G Elnaggar, Abdulmonem Al-Husseini, Marwa A Gaber

Registry-linked trialAbstract read
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In one paragraph

Article in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05658445 (Potential Role of microRNA 410 and BIRC7 Pathways in Recurrent Spontaneous Miscarriage), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05658445 completednot on this map

Potential Role of microRNA 410 and BIRC7 Pathways in Recurrent Spontaneous Miscarriage

Typeobservational_patient_registrySponsorAssiut UniversityRan2023 to 2025Enrolled86ConditionsAbortion, HabitualArmsevacuation
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nesma G FaragMedical Biochemistry and Molecular Biology Department, Faculty of Medicine, Assiut University, Assiut, Egypt. nesma_farag@med.aun.edu.eg.ORCID http://orcid.org/0000-0001-7208-0159
Amany O MohamedMedical Biochemistry and Molecular Biology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
Mahmoud Abdel-AleemGynecology & Obstetric Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
Thorya S El-DeebMedical Biochemistry and Molecular Biology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
Shimaa A ElghazallyOccupational and Environmental Medicine, Faculty of Medicine, Assiut University, Assiut, Egypt.
Mohamed G ElnaggarClinical Pathology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.
Abdulmonem Al-HusseiniMedical student, Faculty of Medicine, Assiut University, Assiut, Egypt.
Marwa A GaberMedical Biochemistry and Molecular Biology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.

Funding

Assuit Medical School Grant Office 2023-01-22-002
6 · The paper itself

Abstract

backgroundSuccessful pregnancy requires a combination of factors, including a healthy embryo with high growth potential and an ideal intrauterine environment with appropriate hormonal levels [Dimitriadis E, Menkhorst E, Saito S, et al. in Nature reviews Disease primers 6(1): 98, 2020]. Abnormalities in maternal genetics and the correlated immune system negatively affect embryo implantation and subsequent placentation [Alecsandru D, Klimczak AM, Velasco JAG, Pirtea P, et al in Fertility and sterility 115(3): 561-566, 2021]. Given the central roles of trophoblast invasion, adhesion, and apoptosis in early placental development, dysregulation of key regulatory pathways may contribute to recurrent miscarriage (RM).

methodForty-three patients with a history of RM (age <35) and 43 healthy controls of the same age were included in this case-control study. qRTPCR was used to estimate the expression of miR-410-5p, ITGA6, and BIRC7in chorionic villous samples. To complement these transcriptional findings, serum levels of ITGA6, livin, and caspase-3 were measured by ELISA. Clinical characteristics of both groups were evaluated.

resultsmiR-410-5p expression was significantly higher, whereas ITGA6 and BIRC7 gene expression was lower in RM patients compared with controls. The patient group had significantly elevated levels of serum caspase-3 protein, which were inversely correlated with both BIRC7 gene expression and BIRC7 protein levels. These results indicate a potential link between elevated apoptosis in RM and dysregulation of the miR-410-5p/ITGA6 axis and BIRC7-related anti-apoptotic signaling pathways.ClinicalTrials.gov registration: NCT05658445

Indexed as

Abortion, HabitualInhibitor of Apoptosis ProteinsMicroRNAsAdultApoptosisCase-Control StudiesCaspase 3EgyptFemaleHumansNeoplasm ProteinsPregnancySignal TransductionCaspase 3Inhibitor of Apoptosis ProteinsMicroRNAsNeoplasm ProteinsBIRC7 geneCaspase-3 proteinIntegrin alpha 6 geneMacrophage polarizationMiR-410-5pRecurrent miscarriage

Identifiers

PMID41995997

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.