ArticleBioMed research international2026
Heterocycle-Tethered Aurones: Synthesis and Evaluation of α-Glucosidase Inhibition.
Article in BioMed research international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
A wide range of heterocycle-tethered aurones were synthesized using an efficient approach for the capture of in situ generated aurone-based ortho-quinone methide intermediates by 3-(2-hydroxyphenyl)enaminones and further ring-opening and ring-closure reaction with bidentate nucleophiles. The synthesized compounds were investigated in vitro as inhibitors of Saccharomyces cerevisiae α-glucosidase. The activity of the methylene-linked heterocycle-aurone hybrids with substituted pyrazole or isoxazole moieties was found to be similar to that of chromone-aurones and significantly exceeded the activity of corresponding aurones with pyrimidine or pyrazolo[1,5-a]pyrimidine fragments. The azole-aurone compounds can exhibit high inhibitory potency towards α-glucosidase with IC
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