ArticlePloS one2026
Evaluation of the predictive accuracy of QUICKI and McAuley indices for insulin resistance in adolescents: Insights from a cross-sectional study.
Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Different indirect methods have been developed to assess insulin resistance (IR), though their validation has been limited to adult populations. In this sense, the study aim is to compare the predictive capacity of the McAuley, QUICKI, SPISE indices, and glucose-insulin ratio against insulin resistance (IR) in Spanish adolescents and to establish reliable cut-off values for these indices in this population. A cross-sectional study was conducted with 981 adolescents aged 11-16 years, from Southern Spain. Anthropometric measurements and fasting biochemical parameters, were assessed. IR indices, such as HOMA-IR, QUICKI, the McAuley index, SPISE, and the glucose-insulin ratio, were calculated. The ability of each index to predict IR was evaluated using multivariate regression analysis and receiver operating characteristic (ROC) curves. Boys exhibited higher waist circumference, triglyceride levels, and fasting insulin levels, while girls had a higher percentage of body fat (p < 0.05). HOMA-IR values increased in adolescents with obesity, whereas McAuley and QUICKI indices decreased significantly (p < 0.05). Similar results were found in adolescents with MetS in comparison to non-MetS adolescents. QUICKI showed the highest predictive accuracy (AUC: 1.00), followed by the McAuley index (AUC: 0.983 in boys, 0.977 in girls), and SPISE (AUC: 0.896 in boys, 0.852 in girls). The cut-off points for these indices were 5.794,0.316, and 7.8 respectively, both for boys and girls. The glucose-insulin ratio demonstrated poor predictive ability. The QUICKI, McAuley, and SPISE indices are effective in predicting IR among Spanish adolescents. Their use could aid in early detection of metabolic and cardiovascular disfunctions, though further validation in larger cohorts is required for clinical application.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.