Evidence map›Paper›PMID 41997124›Full record

ReviewCell2026

Accelerating discovery of cancer causes for prevention in the era of rising early-onset cancers.

Mengyao Shi, Gary J Patti, Marc J Gunter, Ramaswamy Govindan, Iris Lansdorp-Vogelaar, Ting Wang, Jeffrey P Townsend, Graham A Colditz, Yasmine Belkaid, Yin Cao

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mengyao ShiDivision of Public Health Sciences, Department of Surgery, Washington University School of Medicine in St. Louis, St. Louis, MO, USA; Division of Biology and Biomedical Sciences, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Gary J PattiDepartment of Chemistry, Washington University in St. Louis, St. Louis, MO, USA; Center for Mass Spectrometry and Metabolic Tracing, Washington University in St. Louis, St. Louis, MO, USA; Department of Medicine, Washington University School of Medicine in St. Louis, St. Louis, MO, USA; Department of Genetics, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Marc J GunterNutrition and Metabolism Branch, International Agency for Research on Cancer, WHO, Lyon, France; Cancer Epidemiology and Prevention Research Unit, School of Public Health, Imperial College London, London, UK.
Ramaswamy GovindanDivision of Oncology, Department of Medicine, Washington University School of Medicine in St. Louis, St. Louis, MO, USA; Alvin J. Siteman Cancer Center, Barnes-Jewish Hospital and Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Iris Lansdorp-VogelaarDepartment of Public Health, Erasmus Medical Center, Rotterdam, the Netherlands.
Ting WangDepartment of Genetics, Washington University School of Medicine in St. Louis, St. Louis, MO, USA; Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA; McDonnell Genome Institute, Washington University School of Medicine in St. Louis, St. Louis, MO, USA; Department of Computer Science and Engineering, Washington University in St. Louis, St. Louis, MO, USA.
Jeffrey P TownsendDepartment of Biostatistics, Yale School of Public Health, New Haven, CT, USA; Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT, USA; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA; Program in Genomics, Genetics, and Epigenetics, Yale Cancer Center, New Haven, CT, USA.
Graham A ColditzDivision of Public Health Sciences, Department of Surgery, Washington University School of Medicine in St. Louis, St. Louis, MO, USA; Alvin J. Siteman Cancer Center, Barnes-Jewish Hospital and Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Yasmine BelkaidMetaorganism Unit, Department of Immunology, Institut Pasteur, Paris, France.
Yin CaoDivision of Public Health Sciences, Department of Surgery, Washington University School of Medicine in St. Louis, St. Louis, MO, USA; Alvin J. Siteman Cancer Center, Barnes-Jewish Hospital and Washington University School of Medicine in St. Louis, St. Louis, MO, USA; Division of Gastroenterology, Department of Medicine, Washington University School of Medicine in St. Louis, St. Louis, MO, USA; Center for Translational Bioinformatics, Institute for Informatics, Data Science and Biostatistics, Washington University School of Medicine in St. Louis, St. Louis, MO, USA. Electronic address: yin.cao@wustl.edu.

Funding

Tissue Analysis Imaging CoreP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · 2000 to 2025
$13.7M
WashU-VAI Somatic Mosaicism across Human Tissues (SMaHT) Program Genome Characterization CenterUM1DA058219 · WASHINGTON UNIVERSITY · 2025 to 2025
$6.7M
WashU Somatic Mosaicism across Human Tissues (SMaHT) Program Organizational CenterU24NS132103 · WASHINGTON UNIVERSITY · 2025 to 2025
$1.5M
PROSPECT-Global Consortium and Risk Factor DiscoveryOT2CA297576 · WASHINGTON UNIVERSITY · 2025 to 2025
$1.4M
Obesity, sedentary behaviors, and diet quality for prevention and early detection of early-onset colorectal neoplasiaR37CA246175 · WASHINGTON UNIVERSITY · 2025 to 2025
$554k
NCI NIH HHS OT2 CA297576NCI NIH HHS R37 CA246175NHGRI NIH HHS R01 HG007175NIDA NIH HHS UM1 DA058219NIDDK NIH HHS P30 DK052574NINDS NIH HHS U24 NS132103
6 · The paper itself

Abstract

Cancer in younger adults is rising globally, with notable birth-cohort effects. This epidemiological shift underscores the urgent need to accelerate the identification of novel causes and underlying biological networks, with the aim of translating these insights into prevention and interception strategies. In this perspective, we revisit the major milestones in the discovery of cancer causes and outline challenges that hinder progress. To address these challenges, we advocate closer integration of epidemiologic and mechanistic studies and propose three interconnected frameworks that extend current epidemiologic approaches: a tissue ecosystem-anchored framework for cancer cause discovery, a biological state-based framework for precision cancer risk assessment, and a dynamic framework to characterize cancer preventability. This roadmap aims to stimulate conceptual, resource, and methodological advances to accelerate cancer etiology research and prevention in the era of rising early-onset cancers.

Indexed as

NeoplasmsAge of OnsetAnimalsHumans

Identifiers

PMID41997124
PMCPMC13335011

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.