ArticleBehavioural brain research2026
KMO deletion preserves non-associative learning and SVZ neurogenesis in aging mice.
Article in Behavioural brain research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Activation of the kynurenine pathway (KP) by age-related chronic inflammation has been linked with cognitive decline and altered neurogenesis. When upregulated, kynurenine 3-monooxygenase (KMO), a rate-limiting enzyme, drives the KP toward oxidative metabolism and the production of neurotoxic metabolites. Here, we show that genetic deletion of KMO preserves olfactory habituation and dishabituation, a form of non-associative learning, and alters subventricular zone (SVZ) proliferative and neurogenic activity in aging mice. Olfactory habituation and dishabituation were assessed in young (4-5 months), middle-aged (9-12 months), and old (22-30 months) wild-type (WT) and KMO
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