Evidence map›Paper›PMID 41997947›Full record

ArticleNature communications2026

A decoupling strategy toward spatiotemporal regulation and biomechanical transmission of sandwiched scaffold for osteochondral regeneration.

Xuemiao Liu, Mingze Du, Weiguo Zhang, Kang Tian, Fuzhen Yuan, Xing Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xuemiao Liu *Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.ORCID http://orcid.org/0000-0002-8978-909X
Mingze Du *Department of Sports Medicine, Peking University Third Hospital, Beijing, 100191, China.
Weiguo ZhangDepartment of Bone & Joint, First Affiliated Hospital of Dalian Medical University, Dalian, 116000, China.
Kang TianDepartment of Bone & Joint, First Affiliated Hospital of Dalian Medical University, Dalian, 116000, China. dmu-tiankang@outlook.com.
Fuzhen YuanDepartment of Sports Medicine, Peking University Third Hospital, Beijing, 100191, China. yuanfuzhen@pku.edu.cn.
Xing WangBeijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China. wangxing@iccas.ac.cn.ORCID http://orcid.org/0000-0003-3926-1999

Funding

National Natural Science Foundation of China (National Science Foundation of China) 52373162 and 52573186Natural Science Foundation of Beijing Municipality (Beijing Natural Science Foundation) L252122
6 · The paper itself

Abstract

Osteochondral repair remains a great challenge due to the hierarchical complexity and functional heterogeneity. Despite significant efforts in gradient scaffolds, few strategies concern wavy interface and biomechanical functions of calcified cartilage layer (CCL) between the chondro-osseous junction. Here, a sandwich-layered hydrogel containing a biomimetic wavy CCL is developed with hypoxia-inducible capacity, spatiotemporal regulation and biomechanical transmission using a decoupling strategy. The scaffold presents intrinsic Fe

Indexed as

Cartilage, ArticularChondrogenesisRegenerationTissue ScaffoldsAnimalsBiomechanical PhenomenaChondrocytesHydrogelsHypoxia-Inducible Factor 1, alpha SubunitOsteogenesisRabbitsTissue EngineeringHydrogelsHypoxia-Inducible Factor 1, alpha Subunit

Identifiers

PMID41997947
PMCPMC13272660

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.