Evidence map›Paper›PMID 41998146›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2026

Dopaminergic hypersensitivity of the opioid-responsive striatal-entopeduncular pathway in a rodent model of restless legs syndrome.

Marta Valle-León, William Rea, César Quiroz, William N Sánchez, Sandra Albornoz, Ana M Rule, Ning-Sheng Cai, Francisco Ciruela, Christopher J Earley, Sergi Ferré

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marta Valle-LeónIntegrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.
William ReaIntegrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.
César QuirozIntegrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.
William N SánchezIntegrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-7723-0064
Sandra AlbornozDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Ana M RuleDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Ning-Sheng CaiIntegrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.
Francisco CiruelaDepartment of Pathology and Experimental Therapeutics, School of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, L' Hospitalet de Llobregat, Spain.ORCID http://orcid.org/0000-0003-0832-3739
Christopher J EarleyCenter for Restless Legs Study, Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.
Sergi FerréIntegrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA. sferre@intra.nida.nih.gov.ORCID http://orcid.org/0000-0002-1747-1779

Funding

Neurotransmitter Receptor Heteromers in the Striatal Spine ModuleZIADA000493 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI FERRE, SERGI · 2009 to 2025
$35.6M
ICP-QQQS10OD030355 · OD · JOHNS HOPKINS UNIVERSITY · PI RULE, ANA MARIA · 2021 to 2021
$350k
Intramural NIH HHS ZIA DA000493NIH HHS S10 OD030355U.S. Department of Health & Human Services | National Institutes of Health (NIH) S10OD030355
6 · The paper itself

Abstract

We hypothesized that Restless Legs Syndrome (RLS) and the restlessness of opioid withdrawal share common neurobiological mechanisms based on the efficacy of μ-opioid receptor (MOR) agonists in RLS and the common RLS-like phenotype of patients with opioid withdrawal. We also hypothesized this involves an increased sensitivity of the striatal striosomal neurons that co-express MORs and dopamine D

Indexed as

Analgesics, OpioidCorpus StriatumDopamineEntopeduncular NucleusRestless Legs SyndromeAnimalsBenzazepinesDisease Models, AnimalDopamine Agonistsgamma-Aminobutyric AcidIron DeficienciesMaleMiceMice, Inbred C57BLMotor ActivityNeural PathwaysAnalgesics, OpioidBenzazepinesDopamineDopamine Agonistsgamma-Aminobutyric AcidReceptors, Dopamine D1Receptors, Opioid, muSK&F 81297

Identifiers

PMID41998146
PMCPMC13377859

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.