Trial reportEuropean journal of clinical nutrition2026
Time of day influences caffeine's effects on exercise-induced haemostatic responses in sedentary young men: a randomized crossover trial.
Trial report in European journal of clinical nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCaffeine, a performance-enhancing substance, affects haemostasis. However, the interplay between caffeine, exercise, and circadian rhythms on haemostatic responses remains unclear. This study aimed to investigate the effects of acute caffeine intake on exercise-induced haemostatic responses in sedentary young men at different times of day.
methodsThirty caffeine-naïve sedentary men completed a randomized, double-blind, placebo-controlled crossover study. Each participant performed 4 combined exercise sessions-2 at 07:00 and 2 at 18:00-after ingestion of either caffeine or a placebo. Blood samples were collected pre-exercise, post-exercise, and after 60 minutes of recovery.
resultsAcross all conditions, exercise elicited increases in platelet aggregation, thrombin generation, tPA activity, and clot lysis time. PAI-1 activity was unchanged post-exercise but declined during recovery. Caffeine further augmented exercise-induced increase in platelet aggregation, thrombin generation, and clot lysis time-most notably in the morning-without significantly altering tPA or PAI-1 activity. There was lower platelet aggregation, thrombin generation, PAI-1 activity, and clot lysis time, alongside higher tPA activity in the evening compared to the morning.
conclusionThese findings indicate that morning exercise triggers a greater prothrombotic status than evening exercise, and that acute caffeine intake exacerbates this effect. The enhanced fibrinolytic capacity in the evening may create a more favourable haemostatic setting for exercise and cardiovascular safety, a hypothesis that warrants confirmation with denser sampling protocols.
Indexed as
Identifiers
41998349What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.