Evidence map›Paper›PMID 41998636›Full record

ArticleJournal of nanobiotechnology2026

MnUA-DOX-artesunate hydrogel remodels immunosuppressive tumor microenvironment and prevents postoperative recurrence in triple-negative breast cancer.

Keneng Cai, Run Xia, Mengyao Xu, Wanying Chen, Wenli Cai, Xinyu Liu, Tiantian Guo, Weichi Jiang, Chuyi Yu, Jianjia Feng and 6 more

Abstract read
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Keneng CaiArtemisinin Research Center, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.
Run XiaArtemisinin Research Center, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.
Mengyao XuArtemisinin Research Center, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.
Wanying ChenArtemisinin Research Center, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.
Wenli CaiArtemisinin Research Center, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.
Xinyu LiuArtemisinin Research Center, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.
Tiantian GuoArtemisinin Research Center, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.
Weichi JiangArtemisinin Research Center, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.
Chuyi YuArtemisinin Research Center, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.
Jianjia FengArtemisinin Research Center, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.
Chengli LingHunan academy of Chinese Medicine, Yuehua road, Yuelu district, Changsha, 410013, China.
Sheng ZhouArtemisinin Research Center, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.
Yinhuan ChenThe First Afffliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.
Changsheng DengArtemisinin Research Center, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.
Qin XuArtemisinin Research Center, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.
Jianming LiangArtemisinin Research Center, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China. liangjianming@gzucm.edu.cn.

Funding

National Key Research and Development Program of China 2024YFC2310902Natural Science Foundation of China 82204628Natural Science Foundation of China 82374315Natural Science Foundation of Guangdong Province 2022A1515011312Science and Technology Program of Guangzhou 2024A04J4899Special Projects in Key Areas of Colleges and Universities in Guangdong Province 2022ZDZX2015Young Talent Project of Guangzhou University of Chinese Medicine A1-2601-24-414-110Z76
6 · The paper itself

Abstract

Triple-negative breast cancer (TNBC) remains a formidable clinical challenge because of its high aggressiveness, metastatic potential, and lack of effective therapeutic options. In this study, we developed an injectable multifunctional hydrogel, MND-ART-GEL, by encapsulating immunostimulatory manganese urate (MnUA), the chemotherapeutic agent doxorubicin (DOX), and an artemisinin derivative, artesunate (ART), within a thermosensitive Pluronic F127 matrix. Uric acid crystals (MSU) and manganese ions (Mn

Indexed as

DoxorubicinHydrogelsManganese CompoundsTriple Negative Breast NeoplasmsTumor MicroenvironmentUric AcidAnimalsAntineoplastic AgentsApoptosisCell Line, TumorFemaleHumansMiceNeoplasm Recurrence, LocalOxidative StressSTAT3 Transcription FactorAntineoplastic AgentsDoxorubicinHydrogelsManganese CompoundsSTAT3 Transcription FactorUric Acid

Identifiers

PMID41998636
PMCPMC13220432

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.