ArticleJournal of cardiothoracic surgery2026
The diagnostic value of miR-1299 in acute myocardial infarction.
Article in Journal of cardiothoracic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAcute myocardial infarction (AMI) often occurs suddenly and leads to serious consequences. Therefore, there is an urgent need to find a new biomarker for AMI.
methodsMiR-1299 expression was measured by RT-qPCR. The diagnostic value of miR-1299 in AMI was measured by the receiver operating characteristic (ROC) curve. Chi-squared test was utilized to analyze associations between the clinicopathological characteristics of AMI patients and miR-1299 levels. MiR-1299 was overexpressed or inhibited by transfection in hypoxic H9c2 cells. Then, cell activity and the expression of myocardial injury markers in H9c2 cells were detected.
resultsMiR-1299 was increased in AMI and had a high diagnostic value in AMI. In AMI, the expression level of miR-1299 is closely related to WBC and current smoking. In hypoxic H9c2 cells, the overexpression of miR-1299 reduced the cell viability, while the inhibition of miR-1299 increased the cell viability. In addition, the overexpression of miR-1299 increased cTnⅠ, CK-MB, and MYO, while the inhibition of miR-1299 significantly reduced cTnⅠ, CK-MB, and MYO in hypoxic H9c2 cells.
conclusionMiR-1299 was increased in AMI and had a high diagnostic value. In hypoxic H9c2 cells, miR-1299 regulated proliferation and the expression of myocardial injury markers, suggesting that miR-1299 may be a potential biomarker of AMI.
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