Evidence map›Paper›PMID 41998836›Full record

ArticleJournal of cellular and molecular medicine2026

ARIH2 Ubiquitination Regulates NUPR1 to Inhibit Ferroptosis in Bladder Cancer.

Hannuo Deng, Yuanyuan Mi, Lei Zhang, Yuchen Tan, Guangming He, Zebin Shi, Shenglin Gao, Lifeng Zhang, Li Zuo, Jie Peng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hannuo DengDepartment of Urology, The Second People's Hospital of Changzhou, Changzhou Medical Center, Changzhou, China.
Yuanyuan MiDepartment of Urology, Affiliated Hospital of Jiangnan University, Wuxi, China.ORCID 0000-0003-3456-523X
Lei ZhangDepartment of Urology, The Second People's Hospital of Changzhou, Changzhou Medical Center, Changzhou, China.
Yuchen TanDepartment of Urology, The Second People's Hospital of Changzhou, Changzhou Medical Center, Changzhou, China.
Guangming HeDepartment of Urology, The Second People's Hospital of Changzhou, Changzhou Medical Center, Changzhou, China.
Zebin ShiDepartment of Urology, The Second People's Hospital of Changzhou, Changzhou Medical Center, Changzhou, China.ORCID 0009-0009-6260-2369
Shenglin GaoDepartment of Urology, The Second People's Hospital of Changzhou, Changzhou Medical Center, Changzhou, China.
Lifeng ZhangDepartment of Urology, The Second People's Hospital of Changzhou, Changzhou Medical Center, Changzhou, China.
Li ZuoDepartment of Urology, The Second People's Hospital of Changzhou, Changzhou Medical Center, Changzhou, China.ORCID 0000-0002-3668-004X
Jie PengDepartment of Nursing, Wuxi Huishan District People's Hospital, Wuxi, China.

Funding

Changzhou Health Committee Youth Science and Technology Program QN202227Changzhou Sci&Tech Program CJ20220146Jiangsu Province 333 Project RC202202Jiangsu Province Postdoctoral Research Foundation 2021K588CPostdoctoral Science Startup Foundation BSH202009Postdoctoral Science Startup Foundation BSH202214Science and Technology Project of Changzhou Health Commission ZD202440the Basic Research Project of Changzhou Medical Center CMCB202313the Basic Research Project of Changzhou Medical Center CMCB202319Top Talent of Changzhou "The 14th Five-Year Plan" High-Level Health Talents Training Project 2022CZBJ057Top Talent of Changzhou "The 14th Five-Year Plan" High-Level Health Talents Training Project 2022CZBJ058
6 · The paper itself

Abstract

NUPR1 is a pro-tumorigenic factor in bladder cancer (BLCA), but the mechanisms governing its protein stability remain poorly defined. Here, we identified ARIH2 as an E3 ubiquitin ligase that interacts with NUPR1 in BLCA cells through immunoprecipitation-mass spectrometry (IP-MS), co-immunoprecipitation (Co-IP), and immunofluorescence analyses. ARIH2 overexpression reduced NUPR1 abundance and inhibited BLCA cell proliferation and migration while enhancing apoptosis, whereas ARIH2 knockdown increased NUPR1 expression and promoted malignant phenotypes. Mechanistically, ARIH2 depletion prolonged NUPR1 protein stability and reduced its ubiquitination, indicating that ARIH2 negatively regulates NUPR1 through ubiquitin-mediated degradation. Moreover, NUPR1 overexpression suppressed ferroptosis, as reflected by increased GPX4 and SLC7A11, decreased ACSL4, reduced lipid peroxidation, and diminished Fe

Indexed as

FerroptosisMacrophagesUbiquitinationUbiquitin-Protein LigasesUrinary Bladder NeoplasmsBasic Helix-Loop-Helix ProteinsCell Line, TumorCell MovementCell PolarityCell ProliferationFemaleHumansImmunoprecipitationNeoplasm ProteinsARIH2 protein, humanBasic Helix-Loop-Helix ProteinsNeoplasm ProteinsNUPR1 protein, humanUbiquitin-Protein LigasesARIH2bladder cancerferroptosismacrophage polarizationNUPR1tumour microenvironment

Identifiers

PMID41998836
PMCPMC13090160

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.