Evidence mapPaperPMID 41999427Full record

ReviewNaunyn-Schmiedeberg's archives of pharmacology2026

Exploring the phytochemical composition, ethnomedicinal uses, and therapeutic potential of Prunus species: a comprehensive review.

Jennifer Nambooze, Abhay Prakash Mishra, Manisha Nigam, Veronique Seidel, Susan L Bonnet

Abstract readReview
PubMed Publisher
In one paragraph

Review in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jennifer NamboozeDepartment of Chemistry, University of the Free State, Bloemfontein, South Africa.
Abhay Prakash MishraCosmetics and Natural Products Research Center (CosNat), Naresuan University, Tha Pho, Phitsanulok, Thailand. mishra.ap@nu.ac.th.ORCID http://orcid.org/0000-0002-2224-0852
Manisha NigamDepartment of Biochemistry, Hemvati Nandan Bahuguna Garhwal University, Srinagar Garhwal, Uttarakhand, India.
Veronique SeidelStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK.
Susan L BonnetDepartment of Chemistry, University of the Free State, Bloemfontein, South Africa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prunus L. is a diverse genus of deciduous and evergreen trees and shrubs belonging to the family Rosaceae (subfamily Amygdaloideae), comprising approximately 400-430 species widely distributed across temperate regions. Several species are cultivated globally for ornamental purposes and for commercially important fruits such as plums, almonds, peaches, nectarines, cherries, and apricots. Beyond their economic value, numerous Prunus species have a long history of use in traditional healthcare systems for their ethnomedicinal properties. This review synthesizes current knowledge on the ethnomedicinal applications, phytochemical composition, pharmacological activities, and therapeutic potential of 30 selected Prunus species. An extensive literature survey was conducted across major scientific databases, including PubMed, Scopus, Google Scholar, and SciFinder, as well as published books and proceedings. Chemical and taxonomic data were verified through PubChem and World Flora Online. Phytochemical investigations reveal that Prunus species are rich in phenolic acids, flavonoids, anthocyanins, tannins, terpenoids, and cyanogenic glycosides, which contribute to a broad spectrum of biological activities. Experimental studies report significant anticancer, antioxidant, anti-inflammatory, antidiabetic, cardioprotective, neuroprotective, antihyperlipidemic, antibacterial, and diuretic properties. However, comprehensive mechanistic studies and clinical validations remain limited to a few well-studied species, highlighting substantial research gaps. Future research should focus on the isolation and structural characterization of bioactive constituents, elucidation of molecular mechanisms, integration of omics-based approaches, and the conduct of well-designed clinical and toxicological studies. Sustainable utilization and conservation strategies are also essential to preserve genetic diversity. Overall, this review underscores the significant pharmacological promise of Prunus species and provides a framework for advancing their therapeutic applications.

Indexed as

Medicine, TraditionalPhytochemicalsPlant ExtractsPrunusAnimalsEthnopharmacologyHumansPhytotherapyPhytochemicalsPlant ExtractsBioactive compoundsEthnomedicinal usesPharmacological propertiesPrunusRosaceaeTherapeutic potential

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.