Evidence map›Paper›PMID 41999632›Full record

ArticleThe Journal of infectious diseases2026

Maternal cytomegalovirus serology results by geographic region in a large multicenter United States study.

Brenna L Hughes, Cora MacPherson, Dwight J Rouse, George R Saade, Mara J Dinsmoor, Uma M Reddy, Robert Pass, Donna Allard, Gail Mallett, Rebecca G Clifton and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Brenna L HughesFrom the Departments of Obstetrics and Gynecology of Brown University, Providence, RI, USA.ORCID 0000-0001-8950-1204
Cora MacPhersonThe George Washington University Biostatistics Center, Washington, DC, USA.
Dwight J RouseFrom the Departments of Obstetrics and Gynecology of Brown University, Providence, RI, USA.
George R Saadethe University of Texas Medical Branch, Galveston, TX, USA.
Mara J DinsmoorNorthwestern University, Chicago, IL, USA.ORCID 0000-0002-4643-8871
Uma M ReddyEunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA.
Robert PassDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0003-2029-0247
Donna AllardFrom the Departments of Obstetrics and Gynecology of Brown University, Providence, RI, USA.
Gail MallettNorthwestern University, Chicago, IL, USA.
Rebecca G CliftonThe George Washington University Biostatistics Center, Washington, DC, USA.
Cynthia Gyamfi-BannermanColumbia University, New York, NY, USA.
Michael W Varnerthe University of Utah Health Sciences Center, Salt Lake City, UT, USA.ORCID 0000-0001-9455-3973
William H Goodnightthe University of North Carolina at Chapel Hill, Chapel Hill, Chapel Hill, NC, USA.
Alan T N TitaUniversity of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0002-7244-9056
Maged M CostantineThe Ohio State University, Columbus, OH, USA.ORCID 0000-0003-4076-469X
Geeta K SwamyDuke University, Durham, NC, USA.
Kent D Heybornethe University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA.
Edward K ChienCase Western Reserve University, Cleveland, OH, USA.
Suneet P ChauhanChildren's Memorial Hermann Hospital, Houston, TX, USA.
Yasser Y El-SayedStanford University, Stanford, CA, USA.
Brian M Caseythe University of Texas Southwestern Medical Center, Dallas, TX, USA.
Samuel Parrythe University of Pennsylvania, Philadelphia, PA, USA.
Hyagriv N Simhanthe University of Pittsburgh, Pittsburgh, PA, USA.
Peter G NapolitanoMadigan Army Medical Center, Joint Base Lewis-McChord, WA, USA.
George A MaconesUniversity of Texas at Austin, Austin, TX, USA.

Funding

NICHD Maternal Fetal Medicine Units NetworkU10HD040500 · NICHD · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · PI ROUSE, DWIGHT J · 2001 to 2015
$7.5M
NICHD NIH HHS U10 HD040500
6 · The paper itself

Abstract

Congenital cytomegalovirus (CMV) infection, due to both nonprimary and primary maternal infection, affects nearly 1% of neonates. In conducting a randomized trial of hyperimmune globulin for prevention of congenital CMV infection, we screened over 200,000 pregnancies across the United States for evidence of prior or primary CMV infection and evaluated their geographic variation. Although the majority were seropositive, seroprevalence and primary infection risk varied significantly by geographic region, with seroprevalence the highest (88%) and primary infection (0.2%) the lowest in the Southwest. This variation in seroprevalence by geography may inform planning of public health measures to decrease congenital CMV.

Indexed as

adverse pregnancy outcomescytomegalovirus hyperimmune globulin

Identifiers

PMID41999632
PMCPMC13159563

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.