Evidence map›Paper›PMID 41999740›Full record

ArticleCell genomics2026

Interferon-related inflammaging links epigenetic age acceleration to multimorbidity.

Zhaoli Liu, Athanasios Ziogas, Yihan Zhang, Manoj Kumar Gupta, Konstantin Föhse, Esther Taks, Elisabeth Dulfer, Andrei Sarlea, Lorenzo Ventriglia, Büsra Geckin and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Zhaoli LiuCentre for Individualised Infection Medicine (CiiM), a Joint Venture Between the Helmholtz Centre for Infection Research (HZI) and Hannover Medical School (MHH), Hannover, Germany; TWINCORE, a Joint Venture Between the Helmholtz Centre for Infection Research (HZI) and Hannover Medical School (MHH), Hannover, Germany; National Health Commission Key Laboratory of Cardiovascular Regenerative Medicine, Central China Subcenter of National Center for Cardiovascular Diseases, Henan Cardiovascular Disease Center, Fuwai Central-China Cardiovascular Hospital, Central China Fuwai Hospital of Zhengzhou University, Zhengzhou, China.
Athanasios ZiogasDepartment of Internal Medicine and Radboudumc Community for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands; Biomedical Research Institute, Foundation for Research and Technology, Ioannina, Greece; Laboratory of Biological Chemistry, Department of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece.
Yihan ZhangCentre for Individualised Infection Medicine (CiiM), a Joint Venture Between the Helmholtz Centre for Infection Research (HZI) and Hannover Medical School (MHH), Hannover, Germany; TWINCORE, a Joint Venture Between the Helmholtz Centre for Infection Research (HZI) and Hannover Medical School (MHH), Hannover, Germany.
Manoj Kumar GuptaCentre for Individualised Infection Medicine (CiiM), a Joint Venture Between the Helmholtz Centre for Infection Research (HZI) and Hannover Medical School (MHH), Hannover, Germany; TWINCORE, a Joint Venture Between the Helmholtz Centre for Infection Research (HZI) and Hannover Medical School (MHH), Hannover, Germany.
Konstantin FöhseDepartment of Internal Medicine and Radboudumc Community for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.
Esther TaksDepartment of Internal Medicine and Radboudumc Community for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.
Elisabeth DulferDepartment of Internal Medicine and Radboudumc Community for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.
Andrei SarleaDepartment of Internal Medicine and Radboudumc Community for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.
Lorenzo VentrigliaDepartment of Internal Medicine and Radboudumc Community for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands; Department of Precision Medicine, University of Campania "Luigi Vanvitelli," Naples, Italy.
Büsra GeckinDepartment of Internal Medicine and Radboudumc Community for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.
Mohamad BallanCentre for Individualised Infection Medicine (CiiM), a Joint Venture Between the Helmholtz Centre for Infection Research (HZI) and Hannover Medical School (MHH), Hannover, Germany; TWINCORE, a Joint Venture Between the Helmholtz Centre for Infection Research (HZI) and Hannover Medical School (MHH), Hannover, Germany.
Nienke van UnenCentre for Individualised Infection Medicine (CiiM), a Joint Venture Between the Helmholtz Centre for Infection Research (HZI) and Hannover Medical School (MHH), Hannover, Germany; TWINCORE, a Joint Venture Between the Helmholtz Centre for Infection Research (HZI) and Hannover Medical School (MHH), Hannover, Germany.
Leonie HelderDepartment of Internal Medicine and Radboudumc Community for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.
Stephanie TrittelDepartment of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Peggy RieseDepartment of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Simone MoorlagDepartment of Internal Medicine and Radboudumc Community for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.
Charlotte de BreeDepartment of Internal Medicine and Radboudumc Community for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.
Valerie KoekenCentre for Individualised Infection Medicine (CiiM), a Joint Venture Between the Helmholtz Centre for Infection Research (HZI) and Hannover Medical School (MHH), Hannover, Germany; Department of Internal Medicine and Radboudumc Community for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.
Vera MouritsDepartment of Internal Medicine and Radboudumc Community for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.
Martin JaegerDepartment of Internal Medicine and Radboudumc Community for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.
Frank PesslerCentre for Individualised Infection Medicine (CiiM), a Joint Venture Between the Helmholtz Centre for Infection Research (HZI) and Hannover Medical School (MHH), Hannover, Germany; Research Group Biomarkers for Infectious Diseases, TWINCORE Centre for Experimental and Clinical Infection Research, Hannover, Germany.
Carlos A GuzmánCentre for Individualised Infection Medicine (CiiM), a Joint Venture Between the Helmholtz Centre for Infection Research (HZI) and Hannover Medical School (MHH), Hannover, Germany; Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Leo A B JoostenDepartment of Internal Medicine and Radboudumc Community for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands; Department of Medical Genetics, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Yang LiCentre for Individualised Infection Medicine (CiiM), a Joint Venture Between the Helmholtz Centre for Infection Research (HZI) and Hannover Medical School (MHH), Hannover, Germany; TWINCORE, a Joint Venture Between the Helmholtz Centre for Infection Research (HZI) and Hannover Medical School (MHH), Hannover, Germany; Cluster of Excellence RESIST (EXC 2155), Hanover Medical School, Hannover, Germany; Lower Saxony Center for Artificial Intelligence and Causal Methods in Medicine (CAIMed), Hannover, Germany.
Cheng-Jian XuCentre for Individualised Infection Medicine (CiiM), a Joint Venture Between the Helmholtz Centre for Infection Research (HZI) and Hannover Medical School (MHH), Hannover, Germany; TWINCORE, a Joint Venture Between the Helmholtz Centre for Infection Research (HZI) and Hannover Medical School (MHH), Hannover, Germany.
Mihai G NeteaDepartment of Internal Medicine and Radboudumc Community for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands; Department for Immunology and Metabolism, Life and Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany; Human Genomics Laboratory, University of Medicine and Pharmacy of Craiova, Craiova, Romania. Electronic address: mihai.netea@radboudumc.nl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic systemic inflammation and DNA methylation changes are two major hallmarks of aging, yet their interaction is poorly known. We investigated the relation between circulating inflammatory proteome and epigenetic age acceleration as assessed by DNA methylation in four independent cohorts of different ages and health conditions. Epigenetic age scores known to predict human health span (GrimAge and PhenoAge) were more strongly associated with age-associated inflammatory proteins, frailty, and multimorbidity when compared to epigenetic age scores associated with lifespan (Horvath and Hannum). Mendelian randomization analyses showed that blood concentrations of important inflammatory cytokines associated with the interferon pathway (CXCL9, CXCL10, CCL11, and IL-18) increase with age and are causal drivers of epigenetic age acceleration and age-related diseases. Furthermore, aging was associated with dysregulation of cytokine production capacity in immune cells in response to microbial stimulation. These findings argue that the interferon pathway may represent a target for anti-aging interventions.

Indexed as

AgingEpigenesis, GeneticInflammationInterferonsMultimorbidityAdultAgedAged, 80 and overCytokinesDNA MethylationFemaleHumansMaleMiddle AgedCytokinesInterferonsbiological agingepigenetic age accelerationfrailtyimmunosenescenceinflammagingmultimorbidity

Identifiers

PMID41999740
PMCPMC13261661

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.