Evidence map›Paper›PMID 41999993›Full record

ReviewVirus research2026

From legacy to innovation: A comprehensive review of vaccine platforms against viral infections.

Niloofar Farsiu, Fatemeh Khodadadpour Mahani, Nasir Arefinia, Javad Charostad, Mohammad Pardeshenas, Habibollah Mirzaei, Mohsen Nakhaie, Pouya Hassandarvish, Sazaly AbuBakar

Abstract readReview
In one paragraph

Review in Virus research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Niloofar FarsiuGastroenterology and Hepatology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran.
Fatemeh Khodadadpour MahaniResearch Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran.
Nasir ArefiniaBio Environmental Health Hazards Research Center, Jiroft University of Medical Sciences, Jiroft, Iran.
Javad CharostadDepartment of Microbiology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Mohammad PardeshenasDepartment of Microbiology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Habibollah MirzaeiHepatitis Research Center, Deputy of Research, Lorestan University of Medical Sciences, Khorramabad, Iran.
Mohsen NakhaieResearch Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran; Clinical Research Development Unit, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran. Electronic address: mohsennakhaee1367@gmail.com.
Pouya HassandarvishTropical Infectious Diseases Research & Education Centre, Universiti Malaya, Kuala Lumpur, Malaysia. Electronic address: pouyahassandarvish@um.edu.my.
Sazaly AbuBakarTropical Infectious Diseases Research & Education Centre, Universiti Malaya, Kuala Lumpur, Malaysia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Viral infections continue to pose a substantial global health concern, resulting in extensive morbidity and mortality among various populations. Although conventional vaccinations have been pivotal in managing and eliminating certain viral infections, the introduction of new viruses and the resurgence of existing ones underscore the ongoing necessity for creative immunization techniques. This review offers an extensive examination of both conventional and novel vaccine platforms for preventing viral diseases. It analyzes traditional approaches such as inactivated and attenuated vaccines in conjunction with innovative technologies, including subunit, viral vector-based, DNA, mRNA, and virus-like particle (VLP) vaccines. Furthermore, novel strategies to enhance vaccination efficacy, including nanoparticle-based and plant-derived vaccines, are examined. Each platform is evaluated according to its mode of action, immunogenicity, safety, scalability, and adaptation to novel threats. Empirical instances, especially observations from the COVID-19 pandemic, are employed to underscore the achievements, obstacles, and pragmatic utilization of these tools. By reviewing the scientific foundations and developmental pathways of diverse vaccine strategies, this paper offers a more profound understanding of the evolving landscape of viral vaccine development. Finally, this review emphasizes the critical role of innovation in strengthening global readiness for current and future outbreaks.

Indexed as

Vaccine DevelopmentViral VaccinesVirus DiseasesAnimalsCOVID-19COVID-19 VaccinesHumansVaccinationVaccine EfficacyVaccines, AttenuatedVaccines, DNAVaccines, SubunitVaccines, Virus-Like ParticleCOVID-19 VaccinesVaccines, AttenuatedVaccines, DNAVaccines, SubunitVaccines, Virus-Like ParticleViral VaccinesmRNA vaccinesNanoparticlesPlantsVaccination/methodsViral vector vaccinesVirus-like particles

Identifiers

PMID41999993
PMCPMC13137202

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.