ArticleCell reports2026
Interlocked transcription factor feedback loops maintain and restore adult touch sensation.
Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Intrinsic and non-cell-autonomous roles for the neurodevelopmental syndrome-linked transcription factor UNC-3/EBF.Nature communications · 2026Article
- Continuous negative autoregulation fine-tunes dosage-sensitive transcription factor expression to maintain post-mitotic neuron identity.bioRxiv : the preprint server for biology · 2026Article
- Intrinsic and non-cell autonomous roles for a neurodevelopmental syndrome-linked transcription factor.bioRxiv : the preprint server for biology · 2025Article
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5 authors.
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Abstract
The sense of touch relies on the continuous function of specialized mechanosensory circuits, but the underlying molecular mechanisms remain poorly understood. Here, we report that the conserved transcription factors (TFs) CFI-1 (ARID3) and EGL-5 (HOXA7) jointly maintain in adult Caenorhabditis elegans the molecular identity of two key interneuron types, securing information processing within a mechanosensory circuit. Toggling between normal and low levels of CFI-1 or EGL-5 in adults generates digital-like (ON/OFF) effects both on touch-evoked escape response and interneuron identity. Strikingly, reintroduction of CFI-1 following its prolonged depletion restores escape response defects. Mechanistically, we identify two TF network motifs, a double-positive CFI-1/EGL-5 feedback loop and positive CFI-1 autoregulation, which together "lock-in" the interneuron identity programs. Altogether, this work uncovers a molecular mechanism for maintenance of adult neuron identity and circuit function, offering crucial insights into the restorability of neuronal and behavioral defects caused by mutations or variation in TF-encoding genes.
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