Hypertension and heart failure: Navigating blood pressure targets and medication titration and tolerance.

Irfan Helmy, Mohamad Karnib, Varun Sundaram

Abstract readReview

In one paragraph

Review in Clinical medicine (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Hypertension: A common, yet poorly managed condition. What can we do better?Clinical medicine (London, England) · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Irfan HelmyCase Western Reserve University School of Medicine, Cleveland, OH, USA; Department of Cardiology, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH, USA.

Mohamad KarnibCase Western Reserve University School of Medicine, Cleveland, OH, USA; Department of Cardiology, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH, USA.

Varun SundaramCase Western Reserve University School of Medicine, Cleveland, OH, USA; Department of Cardiology, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH, USA; University Hospitals Cleveland Medical Center, Cleveland, OH, USA. Electronic address: vxs173@case.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This article briefly reviews the latest hypertension guidelines and how they should be individualised in patients with heart failure (HF), including the two specific phenotypes: HF with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF). Key recent trials and guidelines show that HF medications remain beneficial and safe to use even in patients without overt hypertension, provided that they are tolerated. We also outline practical strategies for titration and selection of HF medications, most of which affect BP, in an outpatient setting. These strategies are applicable to both normotensive patients and those with pre-existing hypertension.

Indexed as

Antihypertensive AgentsBlood PressureHeart FailureHypertensionHumansPractice Guidelines as TopicStroke VolumeAntihypertensive AgentsBlood pressure targetsGuideline-directed medical therapyHeart failureHeart failure with preserved ejection fractionHeart failure with reduced ejection fractionHypertension

Identifiers

PMID42002041

DOI10.1016/j.clinme.2026.100584

PMCPMC13187585

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.