Evidence map›Paper›PMID 42002401›Full record

ArticleThe Journal of physiology2026

Exacerbated ATP transmission in the carotid body is linked to glomus cell expansion in spontaneously hypertensive rats.

Igor S A Felippe, Audrys Pauza, Olivia M S Gold, Xin Shen, Fernanda Brognara, Rosanna Roberts Nonu, Dylan K Pen, Aabharika Bose, Emma N Bardsley, Anna P Ponnampalam and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Igor S A FelippeDepartment of Physiology, Manaaki Manawa - The Centre for Heart Research, Faculty of Health & Medical Sciences, University of Auckland, Grafton, Auckland, New Zealand.
Audrys PauzaDepartment of Physiology, Manaaki Manawa - The Centre for Heart Research, Faculty of Health & Medical Sciences, University of Auckland, Grafton, Auckland, New Zealand.
Olivia M S GoldDepartment of Physiology, Manaaki Manawa - The Centre for Heart Research, Faculty of Health & Medical Sciences, University of Auckland, Grafton, Auckland, New Zealand.
Xin ShenDepartment of Physiology, Manaaki Manawa - The Centre for Heart Research, Faculty of Health & Medical Sciences, University of Auckland, Grafton, Auckland, New Zealand.
Fernanda BrognaraDepartment of Physiology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Rosanna Roberts NonuDepartment of Physiology, Manaaki Manawa - The Centre for Heart Research, Faculty of Health & Medical Sciences, University of Auckland, Grafton, Auckland, New Zealand.
Dylan K PenDepartment of Physiology, Manaaki Manawa - The Centre for Heart Research, Faculty of Health & Medical Sciences, University of Auckland, Grafton, Auckland, New Zealand.
Aabharika BoseDepartment of Physiology, Manaaki Manawa - The Centre for Heart Research, Faculty of Health & Medical Sciences, University of Auckland, Grafton, Auckland, New Zealand.
Emma N BardsleyDepartment of Physiology, Manaaki Manawa - The Centre for Heart Research, Faculty of Health & Medical Sciences, University of Auckland, Grafton, Auckland, New Zealand.
Anna P PonnampalamDepartment of Physiology, Manaaki Manawa - The Centre for Heart Research, Faculty of Health & Medical Sciences, University of Auckland, Grafton, Auckland, New Zealand.
Davi J A MoraesDepartment of Physiology and Biophysics, Biomedical Sciences Institute, University of São Paulo, São Paulo, Brazil.
Julian F R PatonDepartment of Physiology, Manaaki Manawa - The Centre for Heart Research, Faculty of Health & Medical Sciences, University of Auckland, Grafton, Auckland, New Zealand.ORCID https://orcid.org/0000-0001-7410-2913

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Health Research Council of New Zealand (HRC) 19/687New Zealand Heart FoundationPartridge Research Laureate AwardSydney Taylor Trust
6 · The paper itself

Abstract

ATP acting on P2X3 receptors contributes to carotid body (CB) hyperexcitability in spontaneously hypertensive rats (SHRs). We investigated whether this reflects altered ATP release and/or impaired ATP metabolism. Using in vitro CB preparations, we quantified ATP release in Wistar rats and SHRs (n = 10 each) and found significantly greater ATP release in SHRs (P = 0.00062). Intracellular ATP depletion in dissociated glomus cells was similar between strains (n = 4 each). Morphometric analysis revealed a disproportionate increase in glomus tissue, measured as tyrosine hydroxylase-positive area, in juvenile SHRs compared with Wistar rats (n = 8 each; P = 5.44 × 10

Indexed as

Adenosine TriphosphateCarotid BodyHypertensionAnimalsBasic Helix-Loop-Helix ProteinsEndothelial PAS Domain-Containing Protein 1MaleRatsRats, Inbred SHRRats, WistarAdenosine TriphosphateBasic Helix-Loop-Helix ProteinsEndothelial PAS Domain-Containing Protein 1adenosineATPcarotid bodychemoreceptorschemoreflexectonucleotidasesEpas1HIF‐2αSHR

Identifiers

PMID42002401
PMCPMC13267684

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.