Evidence map›Paper›PMID 42002809›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Alzheimer's disease and related dementias and related health conditions among American Indian and Alaska Native Medicare beneficiaries.

Manxi Yang, Ruqoyat Abdulsalam, Yuxi Shi, Wenjun Fan, Spero M Manson, Maria M Corrada, Joan O'Connell, Luohua Jiang

Abstract read
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In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Manxi YangDepartment of Epidemiology & Biostatistics, Joe C. Wen School of Population & Public Health, University of California, Irvine, Irvine, California, USA.ORCID 0009-0002-5795-5054
Ruqoyat AbdulsalamCenters for American Indian and Alaska Native Health, Colorado School of Public Health, University of Colorado Anschutz, Aurora, Colorado, USA.
Yuxi ShiDepartment of Epidemiology & Biostatistics, Joe C. Wen School of Population & Public Health, University of California, Irvine, Irvine, California, USA.
Wenjun FanDepartment of Epidemiology & Biostatistics, Joe C. Wen School of Population & Public Health, University of California, Irvine, Irvine, California, USA.
Spero M MansonCenters for American Indian and Alaska Native Health, Colorado School of Public Health, University of Colorado Anschutz, Aurora, Colorado, USA.
Maria M CorradaDepartment of Epidemiology & Biostatistics, Joe C. Wen School of Population & Public Health, University of California, Irvine, Irvine, California, USA.
Joan O'ConnellCenters for American Indian and Alaska Native Health, Colorado School of Public Health, University of Colorado Anschutz, Aurora, Colorado, USA.
Luohua JiangDepartment of Epidemiology & Biostatistics, Joe C. Wen School of Population & Public Health, University of California, Irvine, Irvine, California, USA.ORCID 0000-0002-2281-7260

Funding

Research Education CoreP30AG015292 · NIA · UNIVERSITY OF COLORADO DENVER · PI MANSON, SPERO MARTIN · 1997 to 2022
$12.3M
Longitudinal Study of MRI, Clinical, and Genetic Biomarkers of Cognitive Impairment and Alzheimer's Disease in Elderly American IndiansU54MD000507 · NIMHD · UNIVERSITY OF COLORADO DENVER · PI BUCHWALD, DEDRA S · 2017 to 2021
$6.5M
Dementia epidemiology, health service utilization and treatment costs among American Indian and Alaska Native EldersR01AG061189 · NIA · UNIVERSITY OF COLORADO DENVER · PI JIANG, LUOHUA, OCONNELL, JOAN M · 2019 to 2023
$2.9M
California Department of Public Health CDPH #24-10131NIA NIH HHS P30AG015292NIA NIH HHS R01 AG061189NIA NIH HHS R01AG061189NIMHD NIH HHS U54MD000507University of California, Irvine, Joe C. Wen School of Population and Public Health HealthEquityScholarship
6 · The paper itself

Abstract

introductionAlzheimer's disease and related dementias (ADRD) and its associated factors are not well understood in the American Indian and Alaska Native (AI/AN) population.

methodsWe analyzed Medicare 2019 data for 112,280 AI/AN and 1,010,862 White beneficiaries aged 68+, examining the prevalence of ADRD-related health conditions and their associations with ADRD through logistic regressions.

resultsAI/AN beneficiaries had higher age-adjusted ADRD prevalence (15.6% vs. 13.3%), and a higher prevalence of 5 of 9 Lancet risk factors: diabetes, alcohol use disorder (AUD), tobacco use disorder, visual and hearing impairments. Traumatic brain injury (TBI), AUD, and visual and hearing impairments had stronger associations with ADRD among AI/AN beneficiaries, while depression, diabetes, and hypertension had stronger associations among White beneficiaries. DISCUSSION: Our findings highlight disparities in ADRD and related health conditions between AI/AN and White beneficiaries, potentially due to social and systematic health-care inequalities. Addressing these gaps requires culturally tailored prevention and care strategies.

Indexed as

Alzheimer DiseaseAmerican Indian or Alaska NativeDementiaMedicareAgedAged, 80 and overFemaleHumansMalePrevalenceRisk FactorsUnited StatesWhiteAlzheimer's diseaseAmerican Indian and Alaska Native peopleschronic conditionsdisparitiesMedicare

Identifiers

PMID42002809
PMCPMC13092424

What Socratic holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.