Evidence map›Paper›PMID 42002813›Full record

ReviewCell & bioscience2026

Lactate metabolic reprogramming and lactylation modification: molecular mechanisms reshaping the tumor immunosuppressive microenvironment.

Yuzhang Yuan, Yaping Gao, Jinhui Xue, Haozhe Zhang, Ruiting Liang, Luying Huang, Zehua Wang, Liang Song, Yanru Qin, Jiaoyu Ai

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cell & bioscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuzhang Yuan *Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.
Yaping Gao *Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.
Jinhui XueDepartment of Pathology, Zhengzhou Central Hospital Affiliated of Zhengzhou University, Zhengzhou, 450007, China.
Haozhe ZhangDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.
Ruiting LiangDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.
Luying HuangDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Zehua WangDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.
Liang SongMedical Experiment Center, Shaanxi University of Chinese Medicine, Xianyang, 712000, China.
Yanru QinDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China. yanruqin@163.com.ORCID http://orcid.org/0000-0003-2175-9617
Jiaoyu AiDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China. ndyfy05718@ncu.edu.cn.

Funding

National Natural Science Foundation of China 82160451National Natural Science Foundation of China 82273381
6 · The paper itself

Abstract

The immunosuppressive tumor microenvironment (TME) remains a major therapeutic challenge in oncology. This immunosuppression arises through two synergistic mechanisms: impaired cytotoxic function of T cells and NK cells, and differentiation of immune cells into immunosuppressive subtypes. Metabolic reprogramming, particularly the Warburg effect (aerobic glycolysis in tumor cells), plays a pivotal role in shaping this immunosuppressive TME. While lactate was traditionally viewed as a metabolic byproduct, emerging evidence reveals its profound immunomodulatory functions. As the end-product of glycolysis, lactate actively reshapes immune cell behavior to foster immunosuppression. This review systematically examines: (1) the bidirectional lactate-mediated crosstalk between tumor and immune cells that drives immunosuppression, and (2) current therapeutic strategies targeting lactate metabolism. By elucidating these mechanisms, we aim to advance lactate-targeting approaches for TME reprogramming and improved cancer immunotherapy outcomes.

Indexed as

ImmunosuppressionLactate metabolismMetabolic reprogrammingTumor microenvironmentWarburg effect

Identifiers

PMID42002813
PMCPMC13251116

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.