Evidence map›Paper›PMID 42003115›Full record

ArticleCurrent organic synthesis2026

Synthesis and Reactivity of Indole Derivatives: A Comprehensive Review.

Oumaima Kassi, Souad Zerbib, Mustapha Dib, Abderrafia Hafid, Mostafa Khouili

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In one paragraph

Article in Current organic synthesis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Oumaima KassiLaboratory of Molecular Chemistry, Materials and Catalysis, Faculty of Sciences and Technology, University Sultan Moulay Slimane BP 523, 23000, Beni-Mellal, Morocco.
Souad ZerbibLaboratory of Molecular Chemistry, Materials and Catalysis, Faculty of Sciences and Technology, University Sultan Moulay Slimane BP 523, 23000, Beni-Mellal, Morocco.
Mustapha DibLaboratory of Applied Chemistry and Environment, Mineral Solid Chemistry Team, Faculty of Sciences, Mohammed Premier University, B.P. 717, 60 000, Oujda, Morocco.
Abderrafia HafidLaboratory of Molecular Chemistry, Materials and Catalysis, Faculty of Sciences and Technology, University Sultan Moulay Slimane BP 523, 23000, Beni-Mellal, Morocco.
Mostafa KhouiliLaboratory of Molecular Chemistry, Materials and Catalysis, Faculty of Sciences and Technology, University Sultan Moulay Slimane BP 523, 23000, Beni-Mellal, Morocco.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Indole derivatives, a versatile class of N,O-heterocyclic compounds, due to their biochemical processes, demonstrate a variety of pharmacological characteristics. The indole structure is fundamental in both natural and synthetic chemistry, which contributes enormous opportunities to develop novel synthetic drug molecules. Furthermore, indole derivatives are essential in different applications, as flavoring ingredients, fragrances, and pharmaceutical formulations. From a synthetic perspective, several methods have been developed for indole production. In this review, we report the classical strategies to prepare indole derivatives via Fischer indole synthesis and Skraup synthesis, both of which remain widely employed in the design of complex indole-based heterocyclic compounds. Some green methods and efficient protocols have been discussed to increase yield, selectivity, and sustainability.

Indexed as

Fischerheterocyclic synthesisIndoleserotoninSkrauptryptophan

Identifiers

PMID42003115

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.