Evidence map›Paper›PMID 42003229›Full record

ArticleMagnetic resonance in medicine2026

Single-Breathhold 3D MR Elastography in the Liver, With Simultaneous R2* and PDFF Mapping.

Donovan P Tripp, Anne-Sophie van Schelt, Omar Darwish, Karl P Kunze, Shamsa Al Harthy, Nader S Metwalli, Ahmed M Gharib, Claudia Prieto, René M Botnar, Ralph Sinkus and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Donovan P TrippResearch Department of Imaging Physics and Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.ORCID https://orcid.org/0000-0002-6113-2563
Anne-Sophie van ScheltResearch Department of Imaging Physics and Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.ORCID https://orcid.org/0009-0006-2168-2989
Omar DarwishMR Application Predevelopment, Siemens Healthcare Limited, Erlangen, Germany.ORCID https://orcid.org/0000-0003-4747-9007
Karl P KunzeResearch Department of Imaging Physics and Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.ORCID https://orcid.org/0000-0001-6403-2712
Shamsa Al HarthyResearch Department of Imaging Physics and Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.ORCID https://orcid.org/0009-0001-7913-8349
Nader S MetwalliNational Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.ORCID https://orcid.org/0009-0007-6463-6680
Ahmed M GharibNational Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.ORCID https://orcid.org/0000-0002-2476-481X
Claudia PrietoResearch Department of Imaging Physics and Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.ORCID https://orcid.org/0000-0003-4602-2523
René M BotnarResearch Department of Imaging Physics and Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.ORCID https://orcid.org/0000-0003-2811-2509
Ralph SinkusResearch Department of Imaging Physics and Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.ORCID https://orcid.org/0000-0002-6093-1654
Radhouene NejiResearch Department of Imaging Physics and Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.ORCID https://orcid.org/0000-0002-6543-4390

Funding

British Heart Foundation PG/18/59/33955British Heart Foundation RE/18/2/34213British Heart Foundation RG/20/1/34802Center of Interventional Medicine for Precision and Advanced Cellular Therapy #FB210024Engineering and Physical Sciences Research Council EP/L015226Engineering and Physical Sciences Research Council EP/P001009/1Engineering and Physical Sciences Research Council EP/P007619Engineering and Physical Sciences Research Council EP/P032311/1Engineering and Physical Sciences Research Council EP/V044087/1EPSRC Centre for Doctoral Training in Smart Medical Imaging EP/S022104/1Fondo Nacional de Desarrollo Científico y Tecnológico 1250252Fondo Nacional de Desarrollo Científico y Tecnológico 1250261Millennium Institute for Intelligent Healthcare Engineering ICN2021_004National Institute for Health and Care ResearchSiemens HealthineersTechnische Universität MünchenWellcome EPSRC Centre for Medical Engineering NS/A000049/1
6 · The paper itself

Abstract

purposeTo develop a sequence for the rapid acquisition of MR elastography (MRE) parameters in 3D, with simultaneous measurement of proton-density fat fraction (PDFF) and R

methodsThe proposed sequence uses an interleaved motion-encoding scheme to acquire 3D volumes of all motion encodings and wave offsets from a single series of readouts with constant repetition time. This leads to a highly time-efficient acquisition, which together with incoherent k-space undersampling permits all MRE data to be acquired in a single breathhold. The undersampled volumes are reconstructed using compressed sensing with model-based temporal regularisation. The sequence can be combined with a multi-echo readout to allow 3D PDFF and R

resultsPhantom measurements of all viscoelastic parameters, PDFF, and R

conclusionSingle-breathhold 3D MRE in the liver was achieved with a novel acquisition ordering. The sequence offers 3D elastograms from a 16-s breathhold, or 3D elastograms with co-registered PDFF and R

Indexed as

Elasticity Imaging TechniquesImaging, Three-DimensionalLiverMagnetic Resonance ImagingAdipose TissueAdultAlgorithmsBreath HoldingFemaleHumansImage Interpretation, Computer-AssistedImage Processing, Computer-AssistedMalePhantoms, ImagingProtonsReproducibility of ResultsProtonsliverMASLDMR elastographyPDFFR2*

Identifiers

PMID42003229
PMCPMC13269237

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.