In one paragraphArticle in Circulation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
19 authors.
Jiajie Yan *Departments of Physiology and Cell Biology (J.Y., A.K., S.K., N.R., X.W., A.R., I.D., D.J.B., X.A.), The Ohio State University, Columbus, OH.ORCID 0000-0003-2434-7175 Elena Carrillo *Department of Physiology and Biophysics, Rush University Medical Center, Chicago, IL (J.Y., E.C., J.D., M.Y., J.R., D.J.B., X.A.).
Aaryan KohliDepartments of Physiology and Cell Biology (J.Y., A.K., S.K., N.R., X.W., A.R., I.D., D.J.B., X.A.), The Ohio State University, Columbus, OH.ORCID 0009-0007-4430-6756 Saugat KhanalDepartments of Physiology and Cell Biology (J.Y., A.K., S.K., N.R., X.W., A.R., I.D., D.J.B., X.A.), The Ohio State University, Columbus, OH.ORCID 0000-0002-8860-7389 Nikola RicchiutiDepartments of Physiology and Cell Biology (J.Y., A.K., S.K., N.R., X.W., A.R., I.D., D.J.B., X.A.), The Ohio State University, Columbus, OH.ORCID 0009-0008-1019-3834 Jaime DeSantiagoDepartment of Physiology and Biophysics, Rush University Medical Center, Chicago, IL (J.Y., E.C., J.D., M.Y., J.R., D.J.B., X.A.).
Xiaoping WanDepartments of Physiology and Cell Biology (J.Y., A.K., S.K., N.R., X.W., A.R., I.D., D.J.B., X.A.), The Ohio State University, Columbus, OH.ORCID 0009-0006-0417-3437 Abigail RichardsonDepartments of Physiology and Cell Biology (J.Y., A.K., S.K., N.R., X.W., A.R., I.D., D.J.B., X.A.), The Ohio State University, Columbus, OH.
Mei YangDepartment of Physiology and Biophysics, Rush University Medical Center, Chicago, IL (J.Y., E.C., J.D., M.Y., J.R., D.J.B., X.A.).ORCID 0009-0006-9103-7969 Jesus RondonDepartment of Physiology and Biophysics, Rush University Medical Center, Chicago, IL (J.Y., E.C., J.D., M.Y., J.R., D.J.B., X.A.).ORCID 0009-0005-4654-8631 Le ShenDepartment of Pathology of Surgery, The University of Chicago, Chicago, IL (L.S.).
Qiangrong LiangDepartment of Biomedical Sciences, New York Institute of Technology, College of Osteopathic Medicine, Old Westbury, NY (Q.L.).ORCID 0000-0002-6123-5685 Jaroslaw MellerDepartment of Biostatistics, Health Informatics and Data Sciences, University of Cincinnati College of Medicine, Cincinnati, OH (J.M.).ORCID 0000-0002-1162-8253 Isabelle DeschenesDepartments of Physiology and Cell Biology (J.Y., A.K., S.K., N.R., X.W., A.R., I.D., D.J.B., X.A.), The Ohio State University, Columbus, OH.ORCID 0000-0002-1812-7267 Dan J BareDepartments of Physiology and Cell Biology (J.Y., A.K., S.K., N.R., X.W., A.R., I.D., D.J.B., X.A.), The Ohio State University, Columbus, OH.ORCID 0000-0002-3365-4401 Xun AiDepartments of Physiology and Cell Biology (J.Y., A.K., S.K., N.R., X.W., A.R., I.D., D.J.B., X.A.), The Ohio State University, Columbus, OH.ORCID 0000-0003-0739-0286 Funding
Heart-platelet crosstalk: JNK, AF, and thrombogenesisR01HL146744 · NHLBI · RUSH UNIVERSITY MEDICAL CENTER · PI Xun Ai, Yuchi Han · 2019 to 2026
$3.2MHow Vitamin D Receptor Influences Intestinal BarriersR01DK114126 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Jun Sun · 2018 to 2026
$3.0MVitamin D Receptor Regulation of Microbiota in Intestinal EpitheliaR01DK134343 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Jun Sun · 2023 to 2026
$3.0MAtrial and blood JNK in Postoperative AFR01HL168728 · NHLBI · OHIO STATE UNIVERSITY · PI Xun Ai · 2023 to 2026
$2.7MThe JNK2-NLRP3 nexus in atrial fibrillation and its anti-AF therapeutic potentialsR01AA031056 · NIAAA · OHIO STATE UNIVERSITY · PI Xun Ai · 2024 to 2026
$1.8MMechanistic characterization of JNK2α variants in alcohol-caused heart failureR01AA031805 · NIAAA · OHIO STATE UNIVERSITY · PI Xun Ai · 2025 to 2026
$1.2MNHLBI NIH HHS R01 HL146744NHLBI NIH HHS R01 HL168728NIAAA NIH HHS R01 AA031056NIAAA NIH HHS R01 AA031805NIDDK NIH HHS R01 DK114126NIDDK NIH HHS R01 DK134343
6 · The paper itselfAbstract
backgroundAtrial fibrillation (AF) is the most common arrhythmia and is associated with high morbidity and mortality, particularly in the aging population. Current treatment and prevention strategies remain suboptimal, highlighting the urgent need to better understand the mechanisms underlying aging-associated AF. We recently reported a causal role of the stress-activated kinase JNK2 (c-Jun N-terminal kinase 2) in aging-associated AF pathogenesis, mediated by JNK2-driven sarcoplasmic reticulum Ca
methodsWe used aged mice, intestinal epithelium-specific tight junction OD (occludin) knockdown (OD
resultsWe found that leaky gut significantly activates atrial JNK2, which, in turn, drives Ca
conclusionsActivated JNK2 functions as a pathological nodal integrator of leaky gut-associated stress signals, mediating gut-to-heart crosstalk and driving inflammation-induced AF pathogenesis. Targeting JNK2 may represent a novel therapeutic strategy for AF.
Indexed as
AgingAtrial FibrillationMitogen-Activated Protein Kinase 9AnimalsHumansIntestinal Barrier FunctionIntestinal MucosaMaleMiceMice, Inbred C57BLStress, PhysiologicalMitogen-Activated Protein Kinase 9agingarrhythmiaatrial fibrillationcalcium mishandlingc-Jun N-terminal kinase (JNK)leaky gutstress-response kinaseTNF-α
Identifiers
PMID42003478
PMCPMC13159475
What Socratic holds
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