Evidence map›Paper›PMID 42003579›Full record

ArticleAntimicrobial agents and chemotherapy2026

Fluconazole-induced liver injury in patients with pulmonary cryptococcosis: a comprehensive study integrating clinical cohort analysis, network toxicology, molecular docking, and transcriptomics.

Yiding Xu, Lei Chen, Jie Liu, Qin Wang, Xiaodan Zhu, Minghui Wang, Jianghong Li, Lin Shi, Hongni Jiang

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yiding Xu *Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Lei Chen *Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Jie LiuDepartment of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Qin WangDepartment of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Xiaodan ZhuDepartment of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Minghui WangDepartment of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Jianghong LiDepartment of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.ORCID 0009-0001-8967-9229
Lin ShiDepartment of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.ORCID 0000-0002-4854-0730
Hongni JiangDepartment of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.ORCID 0000-0002-6820-3723

Funding

Fujian Provincial Natural Science Foundation of China 2023J011690Major Project of Guangzhou National Laboratory GZNL2024A02003
6 · The paper itself

Abstract

Fluconazole is key for pulmonary cryptococcosis (PC), but its hepatotoxicity (HT) risk is unclear. This study characterized fluconazole-induced liver injury in HIV-negative PC patients and explored its mechanism. We integrated clinical cohort analysis (

Indexed as

Antifungal AgentsChemical and Drug Induced Liver InjuryCryptococcosisFluconazoleAdultCohort StudiesErb-b2 Receptor Tyrosine KinasesFemaleHumansLiverMaleMiddle AgedMolecular Docking SimulationProto-Oncogene Proteins c-aktTranscriptomeAKT1 protein, humanAntifungal AgentsERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesFluconazoleProto-Oncogene Proteins c-aktcohort studyfluconazolehepatotoxicitymolecular dockingnetwork toxicologypulmonary cryptococcosistranscriptomics

Identifiers

PMID42003579
PMCPMC13231873

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.