ArticleFrontiers in plant science2026
Geographical origin orchestrates acteoside accumulation in
Article in Frontiers in plant science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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11 authors.
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Abstract
Introduction: The geo-authenticity of medicinal plants, exemplified by Methods: This study employed an integrated approach combining targeted quantitative analysis, transcriptomics, and metabolomics to dissect how geographical origin shapes the medicinal quality of Results: Targeted quantification confirmed origin-specific accumulation patterns of key bioactive compounds, most notably a significantly higher acteoside content in roots from the Henan origin. Multi-omics profiling revealed a conserved core molecular response to geographical origin, involving 894 common differentially expressed genes and 443 common differentially abundant metabolites enriched in hormone signaling, primary metabolism, and specialized biosynthesis pathways. While the response amplitude was genotype-dependent (stronger in 'Wen 85-5'), its fundamental architecture was consistent. Crucially, we identified a coordinated upregulation of the entire acteoside biosynthetic network in Henan-sourced roots. This was evidenced by the concerted induction of key structural genes ( Conclusion: This study elucidates that the geo-authenticity of
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