Evidence map›Paper›PMID 42004037›Full record

ArticleiScience2026

Hypothalamic thermoregulatory neurons divergently modulate isoflurane anesthesia via temperature dependent and independent mechanisms.

Shuang Cai, Wen Z Yang, Mao Xu, Huimin Chen, Liang Zhou, Tianyuan Luo, Shouyang Yu, Kan Zhang, Haiying Wang, Tian Yu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shuang CaiDepartment of Anesthesiology, Shanghai Children's Medical Centre, Shanghai Jiao Tong University, Shanghai 200127, China.
Wen Z YangSchool of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Mao XuKey Laboratory of Brain Science, Key Laboratory of Anesthesia and Organ Protection of Ministry of Education (In Cultivation), Zunyi Medical University, Zunyi, Guizhou 563006, China.
Huimin ChenDepartment of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.
Liang ZhouKey Laboratory of Brain Science, Key Laboratory of Anesthesia and Organ Protection of Ministry of Education (In Cultivation), Zunyi Medical University, Zunyi, Guizhou 563006, China.
Tianyuan LuoKey Laboratory of Brain Science, Key Laboratory of Anesthesia and Organ Protection of Ministry of Education (In Cultivation), Zunyi Medical University, Zunyi, Guizhou 563006, China.
Shouyang YuKey Laboratory of Brain Science, Key Laboratory of Anesthesia and Organ Protection of Ministry of Education (In Cultivation), Zunyi Medical University, Zunyi, Guizhou 563006, China.
Kan ZhangDepartment of Anesthesiology, Shanghai Children's Medical Centre, Shanghai Jiao Tong University, Shanghai 200127, China.
Haiying WangDepartment of Anesthesiology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, China.
Tian YuKey Laboratory of Brain Science, Key Laboratory of Anesthesia and Organ Protection of Ministry of Education (In Cultivation), Zunyi Medical University, Zunyi, Guizhou 563006, China.
Jijian ZhengDepartment of Anesthesiology, Shanghai Children's Medical Centre, Shanghai Jiao Tong University, Shanghai 200127, China.
Wei L ShenSchool of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Perioperative hypothermia is common clinically. The neural mechanisms underlying general anesthesia and the hypothermia it induces remain elusive. We found that lower core temperature (T

Indexed as

health scienceshuman physiologyneuroscience

Identifiers

PMID42004037
PMCPMC13091562

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.