Evidence map›Paper›PMID 42004071›Full record

ArticleAmerican journal of cancer research2026

Epigenetic reprogramming of hexokinase domain containing 1 (HKDC1) promotes proliferation in colorectal cancer.

Kuo-Hsing Chen, Liang-Chuan Lai, Liang-In Lin, Chia-Lang Hsu, Yi-Hsin Liang, Been-Ren Lin, Ann-Lii Cheng, Eric Y Chuang, Kun-Huei Yeh

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In one paragraph

Article in American journal of cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kuo-Hsing ChenDepartment of Medical Oncology, National Taiwan University Cancer Center Taipei, Taiwan.
Liang-Chuan LaiGraduate Institute of Physiology, National Taiwan University College of Medicine Taipei, Taiwan.
Liang-In LinDepartment of Laboratory Medicine, National Taiwan University Hospital Taipei, Taiwan.
Chia-Lang HsuGraduate Institute of Oncology, National Taiwan University College of Medicine Taipei, Taiwan.
Yi-Hsin LiangDepartment of Oncology, National Taiwan University Hospital Taipei, Taiwan.
Been-Ren LinDepartment of Surgery, National Taiwan University Hospital Taipei, Taiwan.
Ann-Lii ChengDepartment of Medical Oncology, National Taiwan University Cancer Center Taipei, Taiwan.
Eric Y ChuangBioinformatics and Biostatistics Core, Center of Genomic and Precision Medicine Taipei, Taiwan.
Kun-Huei YehDepartment of Oncology, National Taiwan University Hospital Taipei, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dysregulation of cellular metabolism is one of the hallmarks of cancer. Tumor cells would enhance glycolysis to fuel the phenotypes of rapid proliferation and invasion. This study aims to explore epigenetic reprogramming of glycolysis pathway in colorectal cancer (CRC). CRCs and the adjacent normal colon tissues were profiled by using a comprehensive methylation array (Illumina Methylation EPIC Beadchips) to comprehensively analyze the methylation alterations in the glycolysis pathway. Differentially methylated genes (DMGs) were identified by using β value difference (≥ 0.2 or ≤ -0.2) and Wilcoxon rank-sum test (

Indexed as

cancer metabolismcell cycleColorectal cancerepigeneticsglycolysisHKDC1

Identifiers

PMID42004071
PMCPMC13090482

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.