ArticleAmerican journal of cancer research2026
hsa-circKLK3-25 promotes epithelial-mesenchymal transition and malignant progression of prostate cancer through the JNK/ERK signaling pathway.
Article in American journal of cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Prostate cancer (PCa) is one of the most common malignant tumors in males. Characterized by an insidious onset, the majority of patients are diagnosed at an advanced stage upon initial presentation. Therefore, it is particularly important to find the potential biomarkers for early diagnosis of PCa. The expression and stability of circKLK3-25 in PCa cells were assessed by qRT-PCR and Actinomycin D testing. Cell Counting Kit-8 assay, EdU staining, scratch-wound assay and transwell experiments were used to make clear the influences of circKLK3-25 on the progression of PCa cells. Target miRNAs of circKLK3-25 was analyzed by bioinformatics. Western blot determined the expressions of proteins associated with the JNK/ERK pathway and epithelial-mesenchymal transition (EMT). Finally, subcutaneous xenograft tumor models were formed in nude mice to uncover the interference of circKLK3-25 with PCa progression
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