Evidence map›Paper›PMID 42004077›Full record

ArticleAmerican journal of cancer research2026

Integrated bulk and single-cell transcriptomics with experimental validation to identify calmodulin-related prognostic genes in lung adenocarcinoma.

Zhouyan Lin, Minshu Ao, Yue Hu, Ziyan Yu, Mengyu Lu, Yuchao Dong, Chong Bai, Meng Guo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhouyan LinDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Naval Medical University Shanghai, China.
Minshu AoDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Naval Medical University Shanghai, China.
Yue HuNational Key Laboratory of Immunity and Inflammation & Institute of Immunology, Naval Medical University Shanghai, China.
Ziyan YuNational Key Laboratory of Immunity and Inflammation & Institute of Immunology, Naval Medical University Shanghai, China.
Mengyu LuNational Key Laboratory of Immunity and Inflammation & Institute of Immunology, Naval Medical University Shanghai, China.
Yuchao DongDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Naval Medical University Shanghai, China.
Chong BaiDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Naval Medical University Shanghai, China.
Meng GuoNational Key Laboratory of Immunity and Inflammation & Institute of Immunology, Naval Medical University Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung adenocarcinoma (LUAD) exhibits poor prognosis partly due to dysregulated calcium signaling. Here, we integrated bulk RNA-seq (TCGA/LUAD, n = 440) and single-cell sequencing (GSE131907) to identify calmodulin-related prognostic genes. Differential expression analysis and LASSO-Cox regression identified SPHK1 and ASPM as independent predictors of overall survival (HR = 1.52/1.47,

Indexed as

calmodulinimmune microenvironmentLung adenocarcinomamultiplex immunofluorescenceprognostic modelpseudotime trajectory analysissingle-cell RNA-seq

Identifiers

PMID42004077
PMCPMC13090484

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.