ArticleACS nanoscience Au2026
Ultrasound-Generated Nanoscale Mechanical Stimulation to Regulate Stem Cell Differentiation.
Article in ACS nanoscience Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
Harnessing nanoscale mechanical cues to direct stem cell fate represents a transformative strategy in cell-engineered tissue regeneration. In this study, we demonstrate that low-frequency ultrasound (LFU) induces nanoscale vertical displacements (30-65 nm) at the cell-substrate interface, effectively promoting osteogenic differentiation of human mesenchymal stem cells (hMSCs). Remarkably, this ultrasound-driven mechanotransduction occurs on both soft and rigid matrices, highlighting the robustness of the approach. Daily 30 min LFU treatments over 7 days result in significant osteogenic commitment, as confirmed by immunofluorescence and gene expression analyses. Mechanistically, the response is mediated by RhoA-ROCK-dependent myosin IIA contractility, with pharmacological inhibition validating the pathway's role in LFU-induced osteogenesis. This noninvasive, scalable, and cost-effective LFU treatment offers an interesting alternative to traditional biochemical or scaffold-based methods, paving the way for ultrasound-based bioreactors in regenerative medicine and 3D bone tissue engineering.
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